Literature DB >> 7172405

The effect of timing of a single injection on the toxicity of methotrexate in the rat.

J English, G W Aherne, V Marks.   

Abstract

The possibility of a circadian rhythm in the toxicity of methotrexate was investigated in rats after a single intravenous bolus. Indices of haematological, renal and hepatic toxicity were studied, as were the pharmacokinetics of the drug. All the parameters showed a circadian variation, with maximum toxicity occurring after dosage of 06.00 h and minimum toxicity after dosage at midnight. Administration at the other two time points, 12.00 h and 18.00 h, gave intermediate results.

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Year:  1982        PMID： 7172405     DOI： 10.1007/bf00265390

Source DB:  PubMed          Journal:  Cancer Chemother Pharmacol        ISSN： 0344-5704            Impact factor:   3.333


  22 in total

1.  Temporary remissions in acute leukemia in children produced by folic acid antagonist, 4-aminopteroyl-glutamic acid.

Authors:  S FARBER; L K DIAMOND
Journal:  N Engl J Med       Date:  1948-06-03       Impact factor: 91.245

2.  Improved therapeutic index of methotrexate with "leucovorin rescue".

Authors:  M Levitt; M B Mosher; R C DeConti; L R Farber; R T Skeel; J C Marsh; M S Mitchell; R J Papac; E D Thomas; J R Bertino
Journal:  Cancer Res       Date:  1973-07       Impact factor: 12.701

Review 3.  Methotrexate and the liver.

Authors:  M G Dahl
Journal:  Br J Dermatol       Date:  1969-06       Impact factor: 9.302

4.  Factors altering the responsiveness of mice to hexobarbital.

Authors:  E S Vesell
Journal:  Pharmacology       Date:  1968       Impact factor: 2.547

5.  Renal toxicity of methotrexate.

Authors:  P T Condit; R E Chanes; W Joel
Journal:  Cancer       Date:  1969-01       Impact factor: 6.860

6.  [Diurnal variations evidence of glomerular filtration in the rat (author's transl)].

Authors:  J Cambar; F Lemoigne; C Toussaint
Journal:  Experientia       Date:  1979-12-15

7.  A clinical and pharmacological study of high-dose methotrexate with minimal leucovorin rescue.

Authors:  R G Stoller; H G Kaplan; F J Cummings; P Calabresi
Journal:  Cancer Res       Date:  1979-03       Impact factor: 12.701

8.  Circadian optimization of the treatment of L1210 leukemia with 1-beta-D-arabinofuranosylcytosine, cyclophosphamide, vincristine and methylprednisolone.

Authors:  E R Burns; L E Scheving
Journal:  Chronobiologia       Date:  1980 Jan-Mar

9.  [Nycthemeral variations of blood and urine urea, creatinine and total proteins in rats].

Authors:  J Cambar; F Lemoigne; C Toussaint; C Dost
Journal:  C R Seances Soc Biol Fil       Date:  1978

10.  Development and application of a radioimmunoassay for methotrexate.

Authors:  G W Aherne; E M Piall; V Marks
Journal:  Br J Cancer       Date:  1977-11       Impact factor: 7.640
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  4 in total

1.  Circadian changes in the pharmacokinetics of oral ketoprofen.

Authors:  M Ollagnier; H Decousus; Y Cherrah; F Levi; M Mechkouri; P Queneau; A Reinberg
Journal:  Clin Pharmacokinet       Date:  1987-05       Impact factor: 6.447

2.  The effect of abolition of the endogenous corticosteroid rhythm on the circadian variation in methotrexate toxicity in the rat.

Authors:  J English; G W Aherne; J Arendt; V Marks
Journal:  Cancer Chemother Pharmacol       Date:  1987       Impact factor: 3.333

3.  Circadian pharmacokinetics of methotrexate.

Authors:  B A Robinson; E J Begg; B M Colls; G M Jeffery; J R Sharman
Journal:  Cancer Chemother Pharmacol       Date:  1989       Impact factor: 3.333

4.  Role of methotrexate chronotherapy in collagen-induced rheumatoid arthritis in rats.

Authors:  X Wang; X Yan; F Wang; F Ge; Z Li
Journal:  Z Rheumatol       Date:  2018-04       Impact factor: 1.372
  4 in total

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