Literature DB >> 3930461

Analysis of a new method for assessing activity of combinations of antimicrobials: area under the bactericidal activity curve.

S L Barriere, E Ely, J E Kapusnik, J G Gambertoglio.   

Abstract

We have applied a new method of assessment of bactericidal activity in vivo. Calculation of area under the bactericidal activity curve (AUBC) provides a value which involves both the in-vitro bactericidal activity of the drug and its pharmacokinetics. With this method, the activity of combinations of antimicrobials can be assessed in vivo by comparing the AUBC obtained from the combination vs the sum of AUBC from each drug alone. This method may allow a more rational selection of dosage regimens and drug combinations for the treatment of infections.

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Year:  1985        PMID： 3930461     DOI： 10.1093/jac/16.1.49

Source DB:  PubMed          Journal:  J Antimicrob Chemother        ISSN： 0305-7453            Impact factor:   5.790


  23 in total

Review 1.  Serum bactericidal test.

Authors:  C W Stratton
Journal:  Clin Microbiol Rev       Date:  1988-01       Impact factor: 26.132

2.  Antimicrobial activity of human pancreatic juice and its interaction with antibiotics.

Authors:  E B Minelli; A Benini; C Bassi; H Abbas; M Falconi; F Locatelli; R de Marco; P Pederzoli
Journal:  Antimicrob Agents Chemother       Date:  1996-09       Impact factor: 5.191

Review 3.  Standardization of the serum bactericidal test and its relationship to levels of antimicrobial agents.

Authors:  C W Stratton
Journal:  Eur J Clin Microbiol       Date:  1986-02       Impact factor: 3.267

Review 4.  Role of pharmacokinetics in the outcome of infections.

Authors:  G L Drusano
Journal:  Antimicrob Agents Chemother       Date:  1988-03       Impact factor: 5.191

5.  Effect of protein binding on serum bactericidal activities of ceftazidime and cefoperazone in healthy volunteers.

Authors:  Y W Lam; M H Duroux; J G Gambertoglio; S L Barriere; B J Guglielmo
Journal:  Antimicrob Agents Chemother       Date:  1988-03       Impact factor: 5.191

6.  Effect of dose on pharmacokinetics and serum bactericidal activity of mezlocillin.

Authors:  J F Flaherty; S L Barriere; J Mordenti; J G Gambertoglio
Journal:  Antimicrob Agents Chemother       Date:  1987-06       Impact factor: 5.191

7.  Comparative pharmacokinetics and serum inhibitory activity of clindamycin in different dosing regimens.

Authors:  J F Flaherty; L C Rodondi; B J Guglielmo; J C Fleishaker; R J Townsend; J G Gambertoglio
Journal:  Antimicrob Agents Chemother       Date:  1988-12       Impact factor: 5.191

8.  Continuous infusion versus intermittent administration of ceftazidime in critically ill patients with suspected gram-negative infections.

Authors:  A S Benko; D M Cappelletty; J A Kruse; M J Rybak
Journal:  Antimicrob Agents Chemother       Date:  1996-03       Impact factor: 5.191

9.  Comparison of conventional dosing versus continuous-infusion vancomycin therapy for patients with suspected or documented gram-positive infections.

Authors:  J K James; S M Palmer; D P Levine; M J Rybak
Journal:  Antimicrob Agents Chemother       Date:  1996-03       Impact factor: 5.191

10.  Pharmacokinetic and pharmacodynamic activities of ciprofloxacin against strains of Streptococcus pneumoniae, Staphylococcus aureus, and Pseudomonas aeruginosa for which MICs are similar.

Authors:  J M Hyatt; D E Nix; J J Schentag
Journal:  Antimicrob Agents Chemother       Date:  1994-12       Impact factor: 5.191
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