Literature DB >> 3930165

Potential role of arachidonic acid metabolites in hypoxic pulmonary vasoconstriction.

N F Voelkel, M Morganroth, O C Feddersen.   

Abstract

Hypoxic vasoconstriction is important for lung ventilation/perfusion matching. The mechanism of hypoxic vasoconstriction remains elusive. Arachidonic acid is released from hypoxic tissues; possibly vasoconstricting arachidonate metabolites are involved in hypoxic pulmonary vasoconstriction. Data are presented that consider (a) lipoxygenase product(s) as "local," which could be involved in the hypoxia induced pulmonary vasoconstriction.

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Year:  1985        PMID： 3930165     DOI： 10.1378/chest.88.4_supplement.245s

Source DB:  PubMed          Journal:  Chest        ISSN： 0012-3692            Impact factor:   9.410


  7 in total

1.  Pulmonary hypertension after prolonged hypoxic exposure in mice with a congenital deficiency of Cyp2j.

Authors:  Arkadi Beloiartsev; Maria da Glória Rodrigues-Machado; Guo Ling Zhou; Timothy C Tan; Luca Zazzeron; Robert E Tainsh; Patricio Leyton; Rosemary C Jones; Marielle Scherrer-Crosbie; Warren M Zapol
Journal:  Am J Respir Cell Mol Biol       Date:  2015-05       Impact factor: 6.914

2.  Strain difference in pulmonary vascular responsiveness to hypoxia in rats.

Authors:  X R Jin; M Fan; Z Q Wang; Y C Su; G T Yang; H B Hu; Y P Zhang; C J Feng; Y X Ding; D X Wang
Journal:  J Tongji Med Univ       Date:  1990

3.  Augmentation of hypoxic pulmonary vasoconstriction in the isolated perfused rat lung by in vitro antagonists of endothelium-dependent relaxation.

Authors:  V L Brashers; M J Peach; C E Rose
Journal:  J Clin Invest       Date:  1988-11       Impact factor: 14.808

4.  Endocannabinoid anandamide mediates hypoxic pulmonary vasoconstriction.

Authors:  Daniela Wenzel; Michaela Matthey; Laura Bindila; Raissa Lerner; Beat Lutz; Andreas Zimmer; Bernd K Fleischmann
Journal:  Proc Natl Acad Sci U S A       Date:  2013-10-28       Impact factor: 11.205

Review 5.  Integrative understanding of hypoxic pulmonary vasoconstriction using in vitro models: from ventilated/perfused lung to single arterial myocyte.

Authors:  Hae Young Yoo; Su Jung Park; Hae Jin Kim; Woo Kyung Kim; Sung Joon Kim
Journal:  Integr Med Res       Date:  2014-09-03

6.  OxInflammation at High Altitudes: A Proof of Concept from the Himalayas.

Authors:  Simona Mrakic-Sposta; Denise Biagini; Danilo Bondi; Tiziana Pietrangelo; Alessandra Vezzoli; Tommaso Lomonaco; Fabio Di Francesco; Vittore Verratti
Journal:  Antioxidants (Basel)       Date:  2022-02-11

7.  Deletion of the murine cytochrome P450 Cyp2j locus by fused BAC-mediated recombination identifies a role for Cyp2j in the pulmonary vascular response to hypoxia.

Authors:  Guo Ling Zhou; Arkadi Beloiartsev; Binglan Yu; David M Baron; Weihua Zhou; Rasma Niedra; Naifang Lu; Laurel T Tainsh; Warren M Zapol; Brian Seed; Kenneth D Bloch
Journal:  PLoS Genet       Date:  2013-11-21       Impact factor: 5.917
  7 in total

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