Literature DB >> 2255001

Strain difference in pulmonary vascular responsiveness to hypoxia in rats.

X R Jin1, M Fan, Z Q Wang, Y C Su, G T Yang, H B Hu, Y P Zhang, C J Feng, Y X Ding, D X Wang.   

Abstract

The difference in pulmonary vascular response to hypoxia between Hilltop Sprague-Dawley (HT) rats and Wistar (W) rats was studied. Effects of inhibitor of leukotriene (LT) synthesis or prostaglandin (PG) synthesis on hypoxic pulmonary vasoconstriction (HPV) and chronic pulmonary hypertension were observed, and variations in plasma TXB2 and 6-keto-PGF1 alpha during hypoxia were determined. The results showed that in rats of both strains LTs are the major mediator of HPV, which is also mediated by vasoconstrictive PGs in HT rats, while modulated by vasodilative PGs in W rats. This might be the crucial mechanism responsible for the higher pulmonary vascular responsiveness in HT rats. Differences in the modulating effect of histamine and in the structural feature of pulmonary arteriole might be contributing factors as well.

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Year:  1990        PMID： 2255001     DOI： 10.1007/bf02986450

Source DB:  PubMed          Journal:  J Tongji Med Univ        ISSN： 0257-716X


  8 in total

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Journal:  Am Rev Respir Dis       Date:  1986-06

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Journal:  J Tongji Med Univ       Date:  1989

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Journal:  Am Rev Respir Dis       Date:  1983-01

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Authors:  J T Sylvester; J B Gordon; R L Malamet; R C Wetzel
Journal:  Chest       Date:  1985-10       Impact factor: 9.410

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Journal:  J Appl Physiol Respir Environ Exerc Physiol       Date:  1981-11

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Authors:  N F Voelkel; M Morganroth; O C Feddersen
Journal:  Chest       Date:  1985-10       Impact factor: 9.410
  8 in total
  4 in total

1.  Effects of 3,4-dihydroxyacetophenone on hypoxic vasoconstriction in isolated pulmonary and basilar arterial rings.

Authors:  U Farman; D X Wang; J Deng
Journal:  J Tongji Med Univ       Date:  1994

2.  Effects of dietary oils on pulmonary vascular reactivity and chronic hypoxic pulmonary hypertension in rats.

Authors:  C Y Lu; D X Wang
Journal:  J Tongji Med Univ       Date:  1992

3.  Effects of 3,4-dihydroxyacetophenone (3,4-DHAP) on hypoxic pulmonary and systemic vascular response in dogs.

Authors:  F Ullah; D X Wang; Z Ming; S B Yu
Journal:  J Tongji Med Univ       Date:  1995

4.  Effects of dietary magnesium on pulmonary vascular reactivity and chronic hypoxic pulmonary hypertension in rats.

Authors:  C Y Lu; D X Wang
Journal:  J Tongji Med Univ       Date:  1991
  4 in total

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