Literature DB >> 3928401

Poly ADP-ribosylation--a cellular emergency reaction?

U Wintersberger, E Wintersberger.   

Abstract

We propose that the activation of poly(ADP-ribose) synthetase by DNA damage serves to decrease rapidly and transiently the cellular level of NAD (by production therefrom of poly ADP-ribose). The result is a slow-down of energy-requiring reactions, in particular of replicative DNA synthesis giving cells more time to repair the damage. We do not attribute any specific role to poly ADP-ribosylated proteins in this reaction beyond their action as acceptors for poly ADP-ribose.

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Year:  1985        PMID： 3928401     DOI： 10.1016/0014-5793(85)80369-0

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  4 in total

Review 1.  Poly(ADP-ribosylation) and apoptosis.

Authors:  A I Scovassi; G G Poirier
Journal:  Mol Cell Biochem       Date:  1999-09       Impact factor: 3.396

2.  Temporal changes in chromatin, intracellular calcium, and poly(ADP-ribose) polymerase during Sindbis virus-induced apoptosis of neuroblastoma cells.

Authors:  S Ubol; S Park; I Budihardjo; S Desnoyers; M H Montrose; G G Poirier; S H Kaufmann; D E Griffin
Journal:  J Virol       Date:  1996-04       Impact factor: 5.103

3.  Developmental pattern of poly (ADP-ribose) synthetase and NAD glycohydrolase in the brain of the fetal and neonatal rat.

Authors:  G E Shambaugh; R R Koehler; J A Radosevich
Journal:  Neurochem Res       Date:  1988-10       Impact factor: 3.996

4.  Cytotoxicity of 5-(3-methyl-1-triazeno)imidazole-4-carboxamide (MTIC) on Mer+, Mer+Rem- and Mer- cell lines: differential potentiation by 3-acetamidobenzamide.

Authors:  J M Lunn; A L Harris
Journal:  Br J Cancer       Date:  1988-01       Impact factor: 7.640
  4 in total

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