Literature DB >> 3926629

The human T cell antigen Leu-2 (T8) is encoded on chromosome 2.

G Bruns, P Kavathas, Y Shiloh, K Sakai, J Schwaber, S A Latt, L A Herzenberg.   

Abstract

The locus encoding the human T lymphocyte cell surface antigen Leu-2 has been assigned to chromosome 2 with a DNA mapping panel derived from somatic cell hybrids. The two genomic components identified by a cDNA clone for Leu-2 segregated with human chromosome 2 in all 24 independent hybrid clones examined. The cosegregation of the Leu-2 and immunoglobulin kappa (IgK) loci in hybrids with spontaneous rearrangements of chromosome 2 is consistent with the possibility that the Leu-2 locus is on proximal human 2p near IgK. In the mouse, a locus for a T lymphocyte cell surface antigen with properties similar to Leu-2 is closely linked to the IgK locus on mouse chromosome 6. Hence the syntenic relationship of a gene implicated in T cell killing with the immunoglobulin kappa locus would then be conserved in the mouse and human genomes.

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Year:  1985        PMID： 3926629     DOI： 10.1007/bf00295366

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  29 in total

1.  Recombination between kappa chain genetic markers and the Lyt-3 locus.

Authors:  D M Gibson; S J Maclean; M Cherry
Journal:  Immunogenetics       Date:  1983       Impact factor: 2.846

2.  Regional localization on the human X of DNA segments cloned from flow sorted chromosomes.

Authors:  L M Kunkel; U Tantravahi; M Eisenhard; S A Latt
Journal:  Nucleic Acids Res       Date:  1982-03-11       Impact factor: 16.971

3.  Cloned human and mouse kappa immunoglobulin constant and J region genes conserve homology in functional segments.

Authors:  P A Hieter; E E Max; J G Seidman; J V Maizel; P Leder
Journal:  Cell       Date:  1980-11       Impact factor: 41.582

4.  Antigen recognition by human T lymphocytes is linked to surface expression of the T3 molecular complex.

Authors:  E L Reinherz; S Meuer; K A Fitzgerald; R E Hussey; H Levine; S F Schlossman
Journal:  Cell       Date:  1982-10       Impact factor: 41.582

5.  Isolation of amplified DNA sequences from IMR-32 human neuroblastoma cells: facilitation by fluorescence-activated flow sorting of metaphase chromosomes.

Authors:  N Kanda; R Schreck; F Alt; G Bruns; D Baltimore; S Latt
Journal:  Proc Natl Acad Sci U S A       Date:  1983-07       Impact factor: 11.205

6.  Chromosome localization in normal human cells and neuroblastomas of a gene related to c-myc.

Authors:  M Schwab; H E Varmus; J M Bishop; K H Grzeschik; S L Naylor; A Y Sakaguchi; G Brodeur; J Trent
Journal:  Nature       Date:  1984 Mar 15-21       Impact factor: 49.962

7.  Recent evolution of DNA sequence homology in the pericentromeric regions of human acrocentric chromosomes.

Authors:  D M Kurnit; R L Neve; C C Morton; G A Bruns; N S Ma; D R Cox; H P Klinger
Journal:  Cytogenet Cell Genet       Date:  1984

8.  Selective inhibition of human T cell cytotoxicity at levels of target recognition or initiation of lysis by monoclonal OKT3 and Leu-2a antibodies.

Authors:  U Landegren; U Ramstedt; I Axberg; M Ullberg; M Jondal; H Wigzell
Journal:  J Exp Med       Date:  1982-05-01       Impact factor: 14.307

9.  Gene for the human T cell differentiation antigen Leu-2/T8 is closely linked to the kappa light chain locus on chromosome 2.

Authors:  V P Sukhatme; A C Vollmer; J Erikson; M Isobe; C Croce; J R Parnes
Journal:  J Exp Med       Date:  1985-02-01       Impact factor: 14.307

10.  Genetic correlation of a mouse light chain variable region marker with a thymocyte surface antigen.

Authors:  P D Gottlieb
Journal:  J Exp Med       Date:  1974-11-01       Impact factor: 14.307
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  5 in total

Review 1.  T-cell clones and T-cell receptors.

Authors:  F W Fitch
Journal:  Microbiol Rev       Date:  1986-03

2.  Assignment of the human gamma-crystallin gene cluster (CRYG) to the long arm of chromosome 2, region q33-36.

Authors:  Y Shiloh; T Donlon; G Bruns; M L Breitman; L C Tsui
Journal:  Hum Genet       Date:  1986-05       Impact factor: 4.132

3.  Duplication of the CD8 beta-chain gene as a marker of the man-gorilla-chimpanzee clade.

Authors:  C Delarbre; H Nakauchi; R Bontrop; P Kourilsky; G Gachelin
Journal:  Proc Natl Acad Sci U S A       Date:  1993-08-01       Impact factor: 11.205

4.  Mapping of the human APOB gene to chromosome 2p and demonstration of a two-allele restriction fragment length polymorphism.

Authors:  L S Huang; D A Miller; G A Bruns; J L Breslow
Journal:  Proc Natl Acad Sci U S A       Date:  1986-02       Impact factor: 11.205

5.  Identification and characterization of an Alu-containing, T-cell-specific enhancer located in the last intron of the human CD8 alpha gene.

Authors:  J E Hambor; J Mennone; M E Coon; J H Hanke; P Kavathas
Journal:  Mol Cell Biol       Date:  1993-11       Impact factor: 4.272
  5 in total

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