Literature DB >> 3919142

Gene for the human T cell differentiation antigen Leu-2/T8 is closely linked to the kappa light chain locus on chromosome 2.

V P Sukhatme, A C Vollmer, J Erikson, M Isobe, C Croce, J R Parnes.   

Abstract

We have mapped the gene encoding the T cell differentiation antigen Leu-2/T8 to human chromosome 2 by hybridization of a Leu-2/T8 complementary DNA clone to DNA from a panel of mouse-human cell hybrids. In situ hybridization further localizes the gene to the 2p1 region in close proximity to the Ig kappa light chain gene. The Leu-2/T8 gene translocates with C kappa to chromosome 8 in a Burkitt lymphoma line carrying a t(2;8) translocation. These data support the hypothesis that Leu-2/T8 is the human homologue of the mouse Lyt-2,3 antigen.

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Year:  1985        PMID： 3919142      PMCID： PMC2187568          DOI： 10.1084/jem.161.2.429

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  22 in total

1.  Evidence for close linkage of a mouse light chain marker with the Ly-2,3 locus.

Authors:  D M Gibson; B A Taylor; M Cherry
Journal:  J Immunol       Date:  1978-10       Impact factor: 5.422

2.  Detection of specific sequences among DNA fragments separated by gel electrophoresis.

Authors:  E M Southern
Journal:  J Mol Biol       Date:  1975-11-05       Impact factor: 5.469

3.  Monoclonal antibodies defining distinctive human T cell surface antigens.

Authors:  P Kung; G Goldstein; E L Reinherz; S F Schlossman
Journal:  Science       Date:  1979-10-19       Impact factor: 47.728

4.  Genetic linkage relationships of loci specifying differentiation alloantigens in the mouse.

Authors:  K Itakura; J J Hutton; E A Boyse; L J Old
Journal:  Transplantation       Date:  1972-03       Impact factor: 4.939

5.  Long-term human cytolytic T-cell lines allospecific for HLA-DR6 antigen are OKT4+.

Authors:  A M Krensky; C S Reiss; J W Mier; J L Strominger; S J Burakoff
Journal:  Proc Natl Acad Sci U S A       Date:  1982-04       Impact factor: 11.205

6.  Thymus-dependent membrane antigens in man: inhibition of cell-mediated lympholysis by monoclonal antibodies to TH2 antigen.

Authors:  R L Evans; D W Wall; C D Platsoucas; F P Siegal; S M Fikrig; C M Testa; R A Good
Journal:  Proc Natl Acad Sci U S A       Date:  1981-01       Impact factor: 11.205

7.  Activation of human T lymphocyte subsets: helper and suppressor/cytotoxic T cells recognize and respond to distinct histocompatibility antigens.

Authors:  E G Engleman; C J Benike; F C Grumet; R L Evans
Journal:  J Immunol       Date:  1981-11       Impact factor: 5.422

8.  Selective inhibition of human T cell cytotoxicity at levels of target recognition or initiation of lysis by monoclonal OKT3 and Leu-2a antibodies.

Authors:  U Landegren; U Ramstedt; I Axberg; M Ullberg; M Jondal; H Wigzell
Journal:  J Exp Med       Date:  1982-05-01       Impact factor: 14.307

9.  Genetic correlation of a mouse light chain variable region marker with a thymocyte surface antigen.

Authors:  P D Gottlieb
Journal:  J Exp Med       Date:  1974-11-01       Impact factor: 14.307

10.  Evolutionary conservation of surface molecules that distinguish T lymphocyte helper/inducer and cytotoxic/suppressor subpopulations in mouse and man.

Authors:  J A Ledbetter; R L Evans; M Lipinski; C Cunningham-Rundles; R A Good; L A Herzenberg
Journal:  J Exp Med       Date:  1981-02-01       Impact factor: 14.307
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  25 in total

Review 1.  Comparative map for mice and humans.

Authors:  J H Nadeau; M T Davisson; D P Doolittle; P Grant; A L Hillyard; M R Kosowsky; T H Roderick
Journal:  Mamm Genome       Date:  1992       Impact factor: 2.957

Review 2.  Comparative map for mice and humans.

Authors:  J H Nadeau; M T Davisson; D P Doolittle; P Grant; A L Hillyard; M Kosowsky; T H Roderick
Journal:  Mamm Genome       Date:  1991       Impact factor: 2.957

Review 3.  T-cell clones and T-cell receptors.

Authors:  F W Fitch
Journal:  Microbiol Rev       Date:  1986-03

4.  The gene encoding the T-cell surface protein T4 is located on human chromosome 12.

Authors:  M Isobe; K Huebner; P J Maddon; D R Littman; R Axel; C M Croce
Journal:  Proc Natl Acad Sci U S A       Date:  1986-06       Impact factor: 11.205

5.  One aspartic acid transfer RNA gene is present upstream of the U6 snRNA gene cluster in Drosophila melanogaster.

Authors:  G Das; D Henning; R Reddy
Journal:  Nucleic Acids Res       Date:  1986-10-10       Impact factor: 16.971

6.  Assignment of the human gamma-crystallin gene cluster (CRYG) to the long arm of chromosome 2, region q33-36.

Authors:  Y Shiloh; T Donlon; G Bruns; M L Breitman; L C Tsui
Journal:  Hum Genet       Date:  1986-05       Impact factor: 4.132

7.  Probable involvement of immunoglobulin superfamily genes in most recurrent chromosomal rearrangements from ataxia telangiectasia.

Authors:  A Aurias; B Dutrillaux
Journal:  Hum Genet       Date:  1986-03       Impact factor: 4.132

8.  CD8B, the human equivalent of the mouse Ly-3 gene is localized on chromosome 2.

Authors:  N K Spurr; P N Goodfellow; P Johnson
Journal:  Immunogenetics       Date:  1988       Impact factor: 2.846

9.  Assignment of the T-cell differentiation gene MAL to human chromosome 2, region cen----q13.

Authors:  M A Alonso; D E Barton; U Francke
Journal:  Immunogenetics       Date:  1988       Impact factor: 2.846

10.  Somatic cell mapping of T-cell receptor CD3 complex and CD8 genes in cattle.

Authors:  L Li; A Teale; A Bensaid; S Dunlap; A B Dietz; J E Womack
Journal:  Immunogenetics       Date:  1992       Impact factor: 2.846
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