Literature DB >> 3926628

Mitomycin C-induced mosaicism in C-band regions of human chromosomes 1, 9, 16, and Y.

S Simi.   

Abstract

In order to test the hypothesis that somatic mosaicism involving C-band polymorphism of human chromosomes 1, 9, 16 may arise from mitotic crossing over, peripheral blood lymphocytes from normal males were treated with mitomycin C, which is known to induce somatic crossing over in lower eukaryotes. Evidence is presented which shows that mitomycin C is able to alter the heterochromatic pattern in human lymphocytes.

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Year:  1985        PMID： 3926628     DOI： 10.1007/bf00273449

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  21 in total

1.  CHROMOSOME EXCHANGES IN HUMAN LEUKOCYTES INDUCED BY MITOMYCIN C.

Authors:  M W SHAW; M M COHEN
Journal:  Genetics       Date:  1965-02       Impact factor: 4.562

2.  Evolution of repeated DNA sequences by unequal crossover.

Authors:  G P Smith
Journal:  Science       Date:  1976-02-13       Impact factor: 47.728

3.  The segregation of human chromosome polymorphisms.

Authors:  J A Robinson; K E Buckton; G Spowart; M Newton; P A Jacobs; H J Evans; R Hill
Journal:  Ann Hum Genet       Date:  1976-07       Impact factor: 1.670

4.  Heritable alteration of human constitutive heterochromatin induced by mitomycin C.

Authors:  H Hoehn; G M Martin
Journal:  Exp Cell Res       Date:  1972-11       Impact factor: 3.905

5.  Clonal variants of constitutive heterochromatin of human fibroblasts after recovery from mitomycin treatment.

Authors:  H Hoehn; G M Martin
Journal:  Chromosoma       Date:  1973-08-10       Impact factor: 4.316

6.  Somatic stability of variant C-band heterochromatin.

Authors:  H Hoehn; K Au; L E Karp; G M Martin
Journal:  Hum Genet       Date:  1977-02-11       Impact factor: 4.132

Review 7.  Aspects of evaluation, significance, and evolution of human C-band heteromorphism.

Authors:  B Erdtmann
Journal:  Hum Genet       Date:  1982       Impact factor: 4.132

8.  Polymporphism of human C-band heterochromatin. II. Family studies with suggestive evidence for somatic crossing over.

Authors:  A P Craig-Holmes; F B Moore; M W Shaw
Journal:  Am J Hum Genet       Date:  1975-03       Impact factor: 11.025

9.  Detection of lateral asymmetry in the C-bands of mouse-embryo chromosomes exposed in utero to mitomycin C.

Authors:  S M Tucci; G I Kaye
Journal:  Mutat Res       Date:  1980-08       Impact factor: 2.433

10.  Preferential effect of mitomycin C on constitutive heterochromatin of the Indian muntjac, Muntiacus muntjak.

Authors:  P Gupta; T Sharma
Journal:  Mutat Res       Date:  1980-09       Impact factor: 2.433
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  1 in total

1.  Balanced reciprocal whole arm translocation t(3;9): analysis by fluorescence in situ hybridisation.

Authors:  B Blanco; F Loeza; A Carnevale
Journal:  J Med Genet       Date:  1994-01       Impact factor: 6.318
  1 in total

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