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Literature DB >> 3921962

An unusual genetic code in nuclear genes of Tetrahymena.

Abstract

We have cloned and partially sequenced two histone H3 genes of Tetrahymena thermophila. The DNA sequences strongly suggest that both genes are active in the vegetatively growing cell. Comparison of the derived amino acid sequences of these two genes with the actual sequence of Tetrahymena histone H3 results in the surprising conclusion that TAA codes for glutamine. This represents the first demonstration of a coding function for this termination codon of the "universal" code. This observation has important implications for the evolution of ciliates and of the genetic code.

Entities: Chemical Species

Mesh：

Substances：
Histones
Glutamine
DNA

Year: 1985 PMID： 3921962 PMCID： PMC397576 DOI： 10.1073/pnas.82.8.2452

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

23 in total

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Journal: J Mol Biol Date: 1975-11-05 Impact factor: 5.469

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Journal: Proc Natl Acad Sci U S A Date: 1979-02 Impact factor: 11.205

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Authors: B P Kaine; B B Spear
Journal: Nature Date: 1982-02-04 Impact factor: 49.962

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Authors: H R Mahler
Journal: Ann N Y Acad Sci Date: 1981 Impact factor: 5.691

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Authors: Y Kuchino; T Mita; S Nishimura
Journal: Nucleic Acids Res Date: 1981-09-25 Impact factor: 16.971

86 in total

1. A family of developmentally excised DNA elements in Tetrahymena is under selective pressure to maintain an open reading frame encoding an integrase-like protein.

Authors: J A Gershan; K M Karrer
Journal: Nucleic Acids Res Date: 2000-11-01 Impact factor: 16.971

2. Identification, characterization, and complete amino acid sequence of the conjugation-inducing glycoprotein (blepharmone) in the ciliate Blepharisma japonicum.

Authors: M Sugiura; T Harumoto
Journal: Proc Natl Acad Sci U S A Date: 2001-11-27 Impact factor: 11.205

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Authors: R E Lee; P Kugrens
Journal: Microbiol Rev Date: 1992-12

4. Identification of eRF1 residues that play critical and complementary roles in stop codon recognition.

Authors: Sara E Conard; Jessica Buckley; Mai Dang; Gregory J Bedwell; Richard L Carter; Mohamed Khass; David M Bedwell
Journal: RNA Date: 2012-04-27 Impact factor: 4.942

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Journal: Mol Cell Biol Date: 1990-11 Impact factor: 4.272

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Authors: F Caron
Journal: Experientia Date: 1990-12-01

10. The CNA1 histone of the ciliate Tetrahymena thermophila is essential for chromosome segregation in the germline micronucleus.

Authors: Marcella D Cervantes; Xiaohui Xi; Danielle Vermaak; Meng-Chao Yao; Harmit S Malik
Journal: Mol Biol Cell Date: 2005-10-26 Impact factor: 4.138