| Literature DB >> 3921274 |
Abstract
Ground beef contains an organic solvent extractable mutagenesis modulator. Crude or partially-purified preparations of the activity were applied to the backs of SENCAR or CD-1 mice 5 min before application of 7,12-dimethylbenz[a]anthracene (DMBA). Controls received solvent (acetone) only prior to DMBA. Following 1-2 week intervals promotion was effected with twice-weekly applications of 12-O-tetradecanoylphorbol-13-acetate. Modulator-treated mice consistently developed fewer papillomas and exhibited lower tumor incidences than did positive control mice.Entities:
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Year: 1985 PMID： 3921274 DOI： 10.1093/carcin/6.4.591
Source DB: PubMed Journal: Carcinogenesis ISSN： 0143-3334 Impact factor: 4.944