Literature DB >> 3920634

Novel anti-malarial hydroxynaphthoquinones with potent broad spectrum anti-protozoal activity.

A T Hudson, A W Randall, M Fry, C D Ginger, B Hill, V S Latter, N McHardy, R B Williams.   

Abstract

Novel hydroxynaphthoquinones are reported with outstanding efficacy against Plasmodium, Eimeria and Theileria species. Biochemical evidence is presented for the selective toxicity of these compounds being due to inhibition of parasite respiratory systems.

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Year:  1985        PMID： 3920634     DOI： 10.1017/s0031182000049003

Source DB:  PubMed          Journal:  Parasitology        ISSN： 0031-1820            Impact factor:   3.234


  37 in total

1.  In vitro and in vivo activities of the hydroxynaphthoquinone 566C80 against the cyst form of Toxoplasma gondii.

Authors:  F G Araujo; J Huskinson-Mark; W E Gutteridge; J S Remington
Journal:  Antimicrob Agents Chemother       Date:  1992-02       Impact factor: 5.191

2.  Theileria apicoplast as a target for chemotherapy.

Authors:  Regina Lizundia; Dirk Werling; Gordon Langsley; Stuart A Ralph
Journal:  Antimicrob Agents Chemother       Date:  2008-12-15       Impact factor: 5.191

3.  A rare case of Theileria annulata induced corneal opacity in a calf.

Authors:  Vivek Joshi; S Alam; U Dimri; A G Bhanuprakash; A Gopalakrishnan; Y Ajith
Journal:  J Parasit Dis       Date:  2016-08-13

4.  Elimination of Theileria buffeli infections from cattle by concurrent treatment with buparvaquone and primaquine phosphate.

Authors:  N P Stewart; A J de Vos; N McHardy; N F Standfast
Journal:  Trop Anim Health Prod       Date:  1990-05       Impact factor: 1.559

5.  Development of a murine vertical transmission model for Toxoplasma gondii oocyst infection and studies on the efficacy of bumped kinase inhibitor (BKI)-1294 and the naphthoquinone buparvaquone against congenital toxoplasmosis.

Authors:  Joachim Müller; Adriana Aguado-Martínez; Luis-Miguel Ortega-Mora; Javier Moreno-Gonzalo; Ignacio Ferre; Matthew A Hulverson; Ryan Choi; Molly C McCloskey; Lynn K Barrett; Dustin J Maly; Kayode K Ojo; Wes Van Voorhis; Andrew Hemphill
Journal:  J Antimicrob Chemother       Date:  2017-08-01       Impact factor: 5.790

6.  Jun NH2-terminal kinase is constitutively activated in T cells transformed by the intracellular parasite Theileria parva.

Authors:  Y Galley; G Hagens; I Glaser; W Davis; M Eichhorn; D Dobbelaere
Journal:  Proc Natl Acad Sci U S A       Date:  1997-05-13       Impact factor: 11.205

7.  In vivo monitoring of intracellular ATP levels in Leishmania donovani promastigotes as a rapid method to screen drugs targeting bioenergetic metabolism.

Authors:  J R Luque-Ortega; O M Rivero-Lezcano; S L Croft; L Rivas
Journal:  Antimicrob Agents Chemother       Date:  2001-04       Impact factor: 5.191

8.  Infection with the intracellular protozoan parasite Theileria parva induces constitutively high levels of NF-kappa B in bovine T lymphocytes.

Authors:  V Ivanov; B Stein; I Baumann; D A Dobbelaere; P Herrlich; R O Williams
Journal:  Mol Cell Biol       Date:  1989-11       Impact factor: 4.272

9.  Frequency of drug resistance in Plasmodium falciparum: a nonsynergistic combination of 5-fluoroorotate and atovaquone suppresses in vitro resistance.

Authors:  S Gassis; P K Rathod
Journal:  Antimicrob Agents Chemother       Date:  1996-04       Impact factor: 5.191

10.  Theileria parva infection induces autocrine growth of bovine lymphocytes.

Authors:  D A Dobbelaere; T M Coquerelle; I J Roditi; M Eichhorn; R O Williams
Journal:  Proc Natl Acad Sci U S A       Date:  1988-07       Impact factor: 11.205
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