Literature DB >> 3919771

Gossypol, a potent inhibitor of arachidonate 5- and 12-lipoxygenases.

Y Hamasaki, H H Tai.   

Abstract

Gossypol inhibited 5- and 12-lipoxygenases of rat basophilic leukemia (RBL-1) cells with ID50 of 0.3 microM and 0.7 microM, respectively. Nearly two orders of magnitude of higher concentration of gossypol was required to inhibit prostaglandin synthetase. The inhibition was of a non-competitive type with respect to arachidonate.

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Year:  1985        PMID： 3919771     DOI： 10.1016/0005-2760(85)90173-0

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  13 in total

1.  Docosahexaenoic acid and other dietary polyunsaturated fatty acids suppress leukotriene synthesis by mouse peritoneal macrophages.

Authors:  B R Lokesh; J M Black; J B German; J E Kinsella
Journal:  Lipids       Date:  1988-10       Impact factor: 1.880

Review 2.  12-lipoxygenase: a potential target for novel anti-platelet therapeutics.

Authors:  Jennifer Yeung; Michael Holinstat
Journal:  Cardiovasc Hematol Agents Med Chem       Date:  2011-07-01

3.  Selective inhibition by gossypol of endothelium-dependent relaxations augments relaxations to glyceryl trinitrate in rabbit coeliac artery.

Authors:  U Alheid; C Dudel; U Förstermann
Journal:  Br J Pharmacol       Date:  1987-09       Impact factor: 8.739

4.  Removal of endothelial function in coronary resistance vessels by saponin.

Authors:  E Wiest; V Trach; J Dämmgen
Journal:  Basic Res Cardiol       Date:  1989 Sep-Oct       Impact factor: 17.165

5.  Effects of inhibitors of the lipo-oxygenase family of enzymes on the store-operated calcium current I(CRAC) in rat basophilic leukaemia cells.

Authors:  Maike D Glitsch; Daniel Bakowski; Anant B Parekh
Journal:  J Physiol       Date:  2002-02-15       Impact factor: 5.182

6.  The biosynthesis of oxylipins of linoleic and arachidonic acids by the sewage fungus Leptomitus lacteus, including the identification of 8R-Hydroxy-9Z,12Z-octadecadienoic acid.

Authors:  S R Fox; A Akpinar; A A Prabhune; J Friend; C Ratledge
Journal:  Lipids       Date:  2000-01       Impact factor: 1.880

7.  Gossypol increases expression of the pro-apoptotic BH3-only protein NOXA through a novel mechanism involving phospholipase A2, cytoplasmic calcium, and endoplasmic reticulum stress.

Authors:  Ryan S Soderquist; Alexey V Danilov; Alan Eastman
Journal:  J Biol Chem       Date:  2014-04-28       Impact factor: 5.157

8.  Mechanisms of action of lipoxygenase and cytochrome P-450-mono-oxygenase inhibitors in blocking endothelium-dependent vasodilatation.

Authors:  U Förstermann; U Alheid; J C Frölich; A Mülsch
Journal:  Br J Pharmacol       Date:  1988-03       Impact factor: 8.739

9.  Therapeutic effect of 28-homobrassinolide on leukotriene synthesis in leukemia cells.

Authors:  Chuan He; Zhigang Liu; Jingcao Huang; Ting Liu
Journal:  Cytotechnology       Date:  2017-11-03       Impact factor: 2.058

10.  Antiinflammatory effects of various drugs on acetic acid induced colitis in the rat.

Authors:  L R Fitzpatrick; J S Bostwick; M Renzetti; R G Pendleton; D L Decktor
Journal:  Agents Actions       Date:  1990-06
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