Literature DB >> 3919660

Serum immune complexes in systemic sclerosis: relationship with precipitating nuclear antibodies.

M A French, G Harrison, C A Penning, J Cunningham, P Hughes, N R Rowell.   

Abstract

In a comparative study of antinuclear antibodies (ANA) and immune complexes in the serum of 43 patients with systemic sclerosis (SS) ANA were detected by indirect immunofluorescence on Hep 2 cells and/or double immunodiffusion in 90% of patients, while immune complex assays were positive in 32% of patients. The immune complex assays were positive only in sera containing antibodies to Scl 70, n-RNP, Ro, and La. The presence of immune complexes in SS sera is therefore related to ANA specificity. This might explain the variable findings of several previous studies of immune complexes in SS.

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Year:  1985        PMID： 3919660      PMCID： PMC1001579          DOI： 10.1136/ard.44.2.89

Source DB:  PubMed          Journal:  Ann Rheum Dis        ISSN： 0003-4967            Impact factor:   19.103


  19 in total

1.  Cardiopulmonary manifestations of progressive systemic sclerosis: associations with circulating immune complexes and fluorescent antinuclear antibodies.

Authors:  E Pisko; K Gallup; R Turner; M Parker; A M Nomeir; J Box; J Davis; P Box; H Rothberger
Journal:  Arthritis Rheum       Date:  1979-05

2.  Characterization of a soluble cytoplasmic antigen reactive with sera from patients with systemic lupus erythmatosus.

Authors:  G Clark; M Reichlin; T B Tomasi
Journal:  J Immunol       Date:  1969-01       Impact factor: 5.422

3.  The relationship of defective cell-mediated immunity to visceral disease in systemic sclerosis.

Authors:  P Hughes; S Holt; N R Rowell; I D Allonby; K Janis; J K Dodd
Journal:  Clin Exp Immunol       Date:  1977-05       Impact factor: 4.330

4.  Serological markers in progressive systemic sclerosis: clinical correlations.

Authors:  L J Catoggio; R M Bernstein; C M Black; G R Hughes; P J Maddison
Journal:  Ann Rheum Dis       Date:  1983-02       Impact factor: 19.103

5.  Sjögren's syndrome: association of anti-Ro(SS-A) antibodies with vasculitis, hematologic abnormalities, and serologic hyperreactivity.

Authors:  E L Alexander; F C Arnett; T T Provost; M B Stevens
Journal:  Ann Intern Med       Date:  1983-02       Impact factor: 25.391

6.  The heart in systemic sclerosis.

Authors:  E C LeRoy
Journal:  N Engl J Med       Date:  1984-01-19       Impact factor: 91.245

7.  Circulating immune complexes in patients with progressive systemic sclerosis.

Authors:  K Siminovitch; M Klein; W Pruzanski; S Wilkinson; P Lee; S J Yoon; E Keystone
Journal:  Arthritis Rheum       Date:  1982-10

8.  Circulating immune complexes in systemic scleroderma and generalized morphea.

Authors:  S O'Loughlin; G Tappeiner; R E Jordon
Journal:  Dermatologica       Date:  1980

9.  Antibody-dependent cellular cytotoxicity of human vascular endothelium in systemic sclerosis.

Authors:  C A Penning; J Cunningham; M A French; G Harrison; N R Rowell; P Hughes
Journal:  Clin Exp Immunol       Date:  1984-09       Impact factor: 4.330

10.  Immune complexes in systemic sclerosis; detection by C1q binding, K-cell inhibition and Raji cell radioimmunoassays.

Authors:  P Hughes; J Cunningham; M Day; J C Fitzgerald; M A French; J K Wright; N R Rowell
Journal:  J Clin Lab Immunol       Date:  1983-03
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  6 in total

1.  Serum levels of soluble CD21 in patients with systemic sclerosis.

Authors:  Manabu Tomita; Takafumi Kadono; Norihito Yazawa; Tomohiko Kawashima; Zenshiro Tamaki; Ryuichi Ashida; Hanako Ohmatsu; Yoshihide Asano; Makoto Sugaya; Masahide Kubo; Hironobu Ihn; Kunihiko Tamaki; Shinichi Sato
Journal:  Rheumatol Int       Date:  2010-10-30       Impact factor: 2.631

2.  Immunoglobulin G subclass distribution of autoantibodies in systemic sclerosis, primary biliary cirrhosis, and overlap syndromes.

Authors:  M A French; R M Bernstein
Journal:  Ann Rheum Dis       Date:  1987-06       Impact factor: 19.103

3.  Defective Epstein-Barr virus specific suppressor T cell function in progressive systemic sclerosis.

Authors:  A Kahan; A Kahan; C J Menkes; B Amor
Journal:  Ann Rheum Dis       Date:  1986-07       Impact factor: 19.103

4.  Immune complexes containing scleroderma-specific autoantibodies induce a profibrotic and proinflammatory phenotype in skin fibroblasts.

Authors:  Elena Raschi; Cecilia Beatrice Chighizola; Laura Cesana; Daniela Privitera; Francesca Ingegnoli; Claudio Mastaglio; Pier Luigi Meroni; Maria Orietta Borghi
Journal:  Arthritis Res Ther       Date:  2018-08-29       Impact factor: 5.156

Review 5.  Can Antinuclear Antibodies Have a Pathogenic Role in Systemic Sclerosis?

Authors:  Aurélien Chepy; Louisa Bourel; Vincent Koether; David Launay; Sylvain Dubucquoi; Vincent Sobanski
Journal:  Front Immunol       Date:  2022-06-28       Impact factor: 8.786

Review 6.  Single Cell RNA Sequencing in Autoimmune Inflammatory Rheumatic Diseases: Current Applications, Challenges and a Step Toward Precision Medicine.

Authors:  Tadeja Kuret; Snežna Sodin-Šemrl; Brane Leskošek; Polonca Ferk
Journal:  Front Med (Lausanne)       Date:  2022-01-18
  6 in total

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