Literature DB >> 301448

The relationship of defective cell-mediated immunity to visceral disease in systemic sclerosis.

P Hughes, S Holt, N R Rowell, I D Allonby, K Janis, J K Dodd.   

Abstract

Phytohaemagglutinin-induced lymphocyte transformation and circulating thymus-dependent (T) lymphocyte numbers were studied in twenty-eight patients with systemic sclerosis (SS), in fifty normal controls and eleven elderly controls. Patients with SS were found to have impaired lymphocyte transformation responses which showed a positive correlation with both the number of circulating T lymphocytes and the extent of visceral involvement by the disease. This defect of cell-mediated immunity could not be attributed to the effects of increasing age, corticosteroid treatment, iron and folate deficiency or inhibitory serum factors and may have pathogenetic implications for the disorder.

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Year:  1977        PMID： 301448      PMCID： PMC1540753     

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN： 0009-9104            Impact factor:   4.330


  17 in total

1.  Thymus-dependent (T) lymphocyte deficiency in progressive systemic sclerosis.

Authors:  P Hughes; S Holt; N R Rowell; J Dodd
Journal:  Br J Dermatol       Date:  1976-11       Impact factor: 9.302

2.  A broader spectrum of Sjogren's syndrome and its pathogenetic implications.

Authors:  J J BUNIM
Journal:  Ann Rheum Dis       Date:  1961-03       Impact factor: 19.103

3.  ANTINUCLEAR AND PRECIPITATING AUTOANTIBODIES IN PROGRESSIVE SYSTEMIC SCLEROSIS.

Authors:  J S BECK; J R ANDERSON; K G GRAY; N R ROWELL
Journal:  Lancet       Date:  1963-12-07       Impact factor: 79.321

4.  Scleroderma and its relationship to the "collagenoses": dermatomyositis, lupus erythematosus, rheumatoid arthritis and Sjogren's syndrome.

Authors:  D L TUFFANELLI
Journal:  Am J Med Sci       Date:  1962-02       Impact factor: 2.378

5.  Sjogren's syndrome in association with scleroderma.

Authors:  M A SHEARN
Journal:  Ann Intern Med       Date:  1960-06       Impact factor: 25.391

6.  Defect of cell-mediated immunity in patients with iron-deficiency anaemia.

Authors:  D H Joynson; D M Walker; A Jacobs; A E Dolby
Journal:  Lancet       Date:  1972-11-18       Impact factor: 79.321

7.  Immunological aspects of systemic sclerosis in vitro activity of lymphocytes from patients with the disorder.

Authors:  S Currie; M Saunders; M Knowles
Journal:  Br J Dermatol       Date:  1971-05       Impact factor: 9.302

8.  E and EAC rosetting lymphocytes in patients with carcinoma of bronchus. II. A sequential study of thirty patients: effect of BCG.

Authors:  H M Anthony; J A Kirk; K E Madsen; M K Mason; G H Templeman
Journal:  Clin Exp Immunol       Date:  1975-04       Impact factor: 4.330

9.  Uracil-specific anti-R.N.A. antibodies in scleroderma.

Authors:  D Alarcón-Segovia; E Fishbein; E García-Ortigoza; S Estrada-Parra
Journal:  Lancet       Date:  1975-02-15       Impact factor: 79.321

10.  HOMOLOGOUS DISEASE IN THE ADULT RAT, A MODEL FOR AUTOIMMUNE DISEASE. I. GENERAL FEATURES AND CUTANEOUS LESIONS.

Authors:  P STASTNY; V A STEMBRIDGE; M ZIFF
Journal:  J Exp Med       Date:  1963-10-01       Impact factor: 14.307
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  11 in total

Review 1.  Pathogenesis of scleroderma: the interrelationship of the immune and vascular hypotheses.

Authors:  E M Sternberg
Journal:  Surv Immunol Res       Date:  1985

2.  The association of HLA-B8 with visceral disease in systemic sclerosis.

Authors:  P Hughes; K Gelsthorpe; R W Doughty; N R Rowell; F D Rosenthal; I B Sneddon
Journal:  Clin Exp Immunol       Date:  1978-03       Impact factor: 4.330

3.  Impaired primary in-vitro antibody response in progressive systemic sclerosis patients: rôle of suppressor monocytes.

Authors:  P Segond; D Salliere; P Galanaud; R M Desmottes; P Massias; J N Fiessinger
Journal:  Clin Exp Immunol       Date:  1982-01       Impact factor: 4.330

4.  Serum immune complexes in systemic sclerosis: relationship with precipitating nuclear antibodies.

Authors:  M A French; G Harrison; C A Penning; J Cunningham; P Hughes; N R Rowell
Journal:  Ann Rheum Dis       Date:  1985-02       Impact factor: 19.103

5.  Chromosomal aberrations in patients with primary biliary cirrhosis.

Authors:  A Notghi; U Nestle; G Rittner; P Brissot; H Jouanolle; M Manns; E Schleiermacher; C Rittner
Journal:  Hum Genet       Date:  1990-10       Impact factor: 4.132

6.  Defective Epstein-Barr virus specific suppressor T cell function in progressive systemic sclerosis.

Authors:  A Kahan; A Kahan; C J Menkes; B Amor
Journal:  Ann Rheum Dis       Date:  1986-07       Impact factor: 19.103

7.  Lymphocyte subpopulations and reactivity to mitogens in patients with scleroderma.

Authors:  M Baron; E C Keystone; D D Gladman; P Lee; L Poplonski
Journal:  Clin Exp Immunol       Date:  1981-10       Impact factor: 4.330

8.  Spontaneous lymphocyte-mediated (NK cell) cytotoxicity in systemic sclerosis: a comparison with antibody-dependent lymphocyte (K cell) cytotoxicity.

Authors:  J K Wright; P Hughes; N R Rowell
Journal:  Ann Rheum Dis       Date:  1982-08       Impact factor: 19.103

9.  Long-term follow-up study of 164 patients with definite systemic sclerosis: classification considerations.

Authors:  M Vayssairat; N Baudot; N Abuaf; C Johanet
Journal:  Clin Rheumatol       Date:  1992-09       Impact factor: 2.980

10.  Antibody-dependent and phytohaemagglutinin-induced lymphocyte cytotoxicity in systemic sclerosis.

Authors:  J K Wright; P Hughes; N R Rowell; I B Sneddon
Journal:  Clin Exp Immunol       Date:  1979-04       Impact factor: 4.330
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