Literature DB >> 3919059

Role of the thymus in induction and transfer of vaccination against adjuvant arthritis with a T lymphocyte line in rats.

J Holoshitz, A Matitiau, I R Cohen.   

Abstract

Adjuvant arthritis is an experimental disease of rats induced by immunization to antigens of Mycobacterium tuberculosis. Our observation that arthritis could be induced in irradiated rats by the A2 line of T lymphocytes in the absence of mycobacterial antigens suggested that adjuvant arthritis is an autoimmune disease. Moreover, the A2 line could be used to vaccinate unirradiated rats against the subsequent induction of adjuvant arthritis by active immunization to Mycobacteria. In the present study we found that thymus cells obtained from A2 vaccinated rats could transfer resistance to adjuvant arthritis to naive rats. This indicates that the mechanism of resistance induced by A2 vaccination is probably immunological and involves thymus-derived lymphocytes.

Entities:  

Mesh：

Substances：

Year:  1985        PMID： 3919059      PMCID： PMC423521          DOI： 10.1172/JCI111722

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  19 in total

1.  Development of arthritis, periarthritis and periostitis in rats given adjuvants.

Authors:  C M PEARSON
Journal:  Proc Soc Exp Biol Med       Date:  1956-01

2.  Can chronic and self-perpetuating arthritis in the human be caused by arthrotropic undegraded microbial cell wall constituants? A working hypothesis.

Authors:  I Ginsburg
Journal:  Rheumatol Rehabil       Date:  1977-08

3.  Delayed hypersensitivity reactions to collagen in rats with adjuvant-induced arthritis.

Authors:  C Steffen; G Wick
Journal:  Z Immunitatsforsch Allerg Klin Immunol       Date:  1971

4.  Effector T lymphocyte line cells migrate to the thymus and persist there.

Authors:  Y Naparstek; J Holoshitz; S Eisenstein; T Reshef; S Rappaport; J Chemke; A Ben-Nun; I R Cohen
Journal:  Nature       Date:  1982-11-18       Impact factor: 49.962

5.  Connective tissue disease can develop in rats either spontaneously or after total lymphoid irradiation.

Authors:  D E Trentham; E Brahn; W Williams; W J McCune; J E Belli
Journal:  J Rheumatol       Date:  1984-06       Impact factor: 4.666

6.  Vaccination against autoimmune encephalomyelitis with T-lymphocyte line cells reactive against myelin basic protein.

Authors:  A Ben-Nun; H Wekerle; I R Cohen
Journal:  Nature       Date:  1981-07-02       Impact factor: 49.962

7.  Towards a network theory of the immune system.

Authors:  N K Jerne
Journal:  Ann Immunol (Paris)       Date:  1974-01

8.  Autoimmune encephalomyelitis (EAE) mediated or prevented by T lymphocyte lines directed against diverse antigenic determinants of myelin basic protein. Vaccination is determinant specific.

Authors:  J Holoshitz; A Frenkel; A Ben-Nun; I R Cohen
Journal:  J Immunol       Date:  1983-12       Impact factor: 5.422

9.  T lymphocyte line specific for thyroglobulin produces or vaccinates against autoimmune thyroiditis in mice.

Authors:  R Maron; R Zerubavel; A Friedman; I R Cohen
Journal:  J Immunol       Date:  1983-11       Impact factor: 5.422

10.  Arthritis induced in rats by cloned T lymphocytes responsive to mycobacteria but not to collagen type II.

Authors:  J Holoshitz; A Matitiau; I R Cohen
Journal:  J Clin Invest       Date:  1984-01       Impact factor: 14.808
View more
  4 in total

1.  Toward rigorous comprehension of biological complexity: modeling, execution, and visualization of thymic T-cell maturation.

Authors:  Sol Efroni; David Harel; Irun R Cohen
Journal:  Genome Res       Date:  2003-11       Impact factor: 9.043

2.  Increased activation-induced cell death in peripheral lymphocytes of rheumatoid arthritis patients: the mechanism of action.

Authors:  Xiaolei Tang; David E Yocum; David Dejonghe; Kathryn Nordensson; Douglas F Lake; John Richard
Journal:  Immunology       Date:  2004-07       Impact factor: 7.397

3.  Therapeutic vaccination against adjuvant arthritis using autoimmune T cells treated with hydrostatic pressure.

Authors:  O Lider; N Karin; M Shinitzky; I R Cohen
Journal:  Proc Natl Acad Sci U S A       Date:  1987-07       Impact factor: 11.205

4.  Preventing autoimmune arthritis using antigen-specific immature dendritic cells: a novel tolerogenic vaccine.

Authors:  Igor Popov; Mu Li; Xiufen Zheng; Hongtao San; Xusheng Zhang; Thomas E Ichim; Motohiko Suzuki; Biao Feng; Costin Vladau; Robert Zhong; Bertha Garcia; Gill Strejan; Robert D Inman; Wei-Ping Min
Journal:  Arthritis Res Ther       Date:  2006       Impact factor: 5.156
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.