Literature DB >> 3918823

Total-body scintigraphy with 131I-meta-iodobenzylguanidine for detection of neuroblastoma.

C A Hoefnagel, P A Voûte, J de Kraker, H R Marcuse.   

Abstract

Total-body scintigraphy with 131I-meta-iodobenzylguanidine (131I-MIBG) was performed in 20 patients with neuroblastoma. In patients who were in complete remission no pathological concentration of 131I-MIBG was found. In 16 patients with residual, recurrent or metastatic neuroblastoma the tumor localizations were correctly identified by 131I-MIBG-scintigraphy In 5 patients additional tumor sites were found. In most patients an inverse relationship between myocardial and tumoral concentration of 131I-MIBG was noted. Dosimetric assessment of 131I-MIBG uptake in patients with metastatic disease revealed cases with considerable tracer concentration and long effective half lives in tumor localizations. It is concluded that 131I-MIBG total-body scintigraphy is useful in the diagnosis and follow-up of neuroblastoma and that therapeutic use of this agent is feasible, if patients are selected upon the merits of dosimetry.

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Year:  1985        PMID： 3918823

Source DB:  PubMed          Journal:  Diagn Imaging Clin Med        ISSN： 0254-881X


  8 in total

1.  Menadione inhibits MIBG uptake in two neuroendocrine cell lines.

Authors:  J Cornelissen; G A Tytgat; M van den Brug; A B van Kuilenburg; P A Voûte; A H van Gennip
Journal:  J Neurooncol       Date:  1997-01       Impact factor: 4.130

2.  The role of I-131-MIBG in the diagnosis and therapy of carcinoids.

Authors:  C A Hoefnagel; F C den Hartog Jager; B G Taal; N G Abeling; E E Engelsman
Journal:  Eur J Nucl Med       Date:  1987

3.  Visualization of a ganglioneuroma by means of scintigraphy with 131-I-MIBG.

Authors:  O Caballero; J Ferris; A Verdeguer; C Esquembre; V Castel
Journal:  Eur J Nucl Med       Date:  1986

4.  Cytotoxic and antitumor effects of the norepinephrine analogue meta-iodo-benzylguanidine (MIBG).

Authors:  L A Smets; B Bout; J Wisse
Journal:  Cancer Chemother Pharmacol       Date:  1988       Impact factor: 3.333

5.  A comparison of iodine-123 meta-iodobenzylguanidine scintigraphy and single bone marrow aspiration biopsy in the diagnosis and follow-up of 26 children with neuroblastoma.

Authors:  K Osmanagaoglu; M Lippens; Y Benoit; E Obrie; K Schelstraete; M Simons
Journal:  Eur J Nucl Med       Date:  1993-12

6.  The diagnostic and therapeutic utility of radioiodinated metaiodobenzylguanidine (MIBG). 5 years of experience.

Authors:  L Troncone; V Rufini; P Montemaggi; F M Danza; A Lasorella; R Mastrangelo
Journal:  Eur J Nucl Med       Date:  1990

7.  The efficacy and safety of Iodine-131-metaiodobenzylguanidine therapy in patients with neuroblastoma: a meta-analysis.

Authors:  Huihui He; Qiaoling Xu; Chunjing Yu
Journal:  BMC Cancer       Date:  2022-02-28       Impact factor: 4.430

8.  Evaluation of phenylpiperazines as targeting agents for neuroblastoma.

Authors:  J W Babich; W A Graham; A J Fischman
Journal:  Br J Cancer       Date:  1996-09       Impact factor: 7.640
  8 in total

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