| Literature DB >> 9049842 |
J Cornelissen1, G A Tytgat, M van den Brug, A B van Kuilenburg, P A Voûte, A H van Gennip.
Abstract
In this paper we report on our studies of the effect of menadione on the uptake of MIBG in the neuroendocrine cell lines PC12 and SK-N-SH. Menadione inhibits the uptake of MIBG in both cell lines in a dose-dependent manner. Inhibition of MIBG uptake is most pronounced in the PC12 cell line. Comparison of the inhibitory action of menadione on the uptake and retention of MIBG with that of imipramine and reserpine suggests that menadione inhibits uptake 1 mediated uptake as well as granular storage.Entities:
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Year: 1997 PMID： 9049842 DOI： 10.1023/a:1005718421774
Source DB: PubMed Journal: J Neurooncol ISSN： 0167-594X Impact factor: 4.130