Literature DB >> 3917328

Current issues in the design and interpretation of clinical trials.

S J Pocock.   

Abstract

Though there have been considerable improvements in the use of statistical methods for clinical trials in recent years, there remain major practical difficulties in the design and interpretation of many trials. This paper concentrates on problems relating to randomisation, the overemphasis on significance testing, and the inadequate size of many trials. Each topic is illustrated by examples from recent trials.

Mesh：

Year:  1985        PMID： 3917328      PMCID： PMC1415390          DOI： 10.1136/bmj.290.6461.39

Source DB:  PubMed          Journal:  Br Med J (Clin Res Ed)        ISSN： 0267-0623


  9 in total

1.  Medical Research Council Vitamin Study.

Authors: 
Journal:  Lancet       Date:  1984-06-09       Impact factor: 79.321

2.  Guidelines for publishing papers on cancer clinical trials: responsibilities of editors and authors.

Authors:  M Zelen
Journal:  J Clin Oncol       Date:  1983-02       Impact factor: 44.544

3.  Restricted randomization designs in clinical trials.

Authors:  R Simon
Journal:  Biometrics       Date:  1979-06       Impact factor: 2.571

4.  Effect of diet and smoking intervention on the incidence of coronary heart disease. Report from the Oslo Study Group of a randomised trial in healthy men.

Authors:  I Hjermann; K Velve Byre; I Holme; P Leren
Journal:  Lancet       Date:  1981-12-12       Impact factor: 79.321

5.  D-penicillamine treatment improves survival in primary biliary cirrhosis.

Authors:  O Epstein; S Jain; R G Lee; D G Cook; A M Boss; P J Scheuer; S Sherlock
Journal:  Lancet       Date:  1981-06-13       Impact factor: 79.321

6.  Possible prevention of neural-tube defects by periconceptional vitamin supplementation.

Authors:  R W Smithells; S Sheppard; C J Schorah; M J Seller; N C Nevin; R Harris; A P Read; D W Fielding
Journal:  Lancet       Date:  1980-02-16       Impact factor: 79.321

7.  Allocation of patients to treatment groups in a controlled clinical study.

Authors:  S J White; L S Freedman
Journal:  Br J Cancer       Date:  1978-05       Impact factor: 7.640

8.  Practical experience of randomization in cancer trials: an international survey.

Authors:  S J Pocock; S W Lagakos
Journal:  Br J Cancer       Date:  1982-09       Impact factor: 7.640

9.  Design and analysis of randomized clinical trials requiring prolonged observation of each patient. I. Introduction and design.

Authors:  R Peto; M C Pike; P Armitage; N E Breslow; D R Cox; S V Howard; N Mantel; K McPherson; J Peto; P G Smith
Journal:  Br J Cancer       Date:  1976-12       Impact factor: 7.640
  9 in total
  16 in total

1.  Cementing the evidence: time for a randomized trial of vertebroplasty.

Authors:  J G Jarvik; R A Deyo
Journal:  AJNR Am J Neuroradiol       Date:  2000-09       Impact factor: 3.825

2.  When should we change our clinical practice based on the results of a clinical study? The hierarchy of evidence.

Authors:  Giorgio Costantino; Nicola Montano; Giovanni Casazza
Journal:  Intern Emerg Med       Date:  2015-04-10       Impact factor: 3.397

3.  Clinical trials, statistics, and dilemmas.

Authors:  S McKenzie
Journal:  Arch Dis Child       Date:  1988-03       Impact factor: 3.791

Review 4.  Effects of acebutolol on the serum lipid profile.

Authors:  A Clucas; N Miller
Journal:  Drugs       Date:  1988       Impact factor: 9.546

5.  Using N-of-1 trials to improve patient management and save costs.

Authors:  Paul A Scuffham; Jane Nikles; Geoffrey K Mitchell; Michael J Yelland; Norma Vine; Christopher J Poulos; Peter I Pillans; Guy Bashford; Chris del Mar; Philip J Schluter; Paul Glasziou
Journal:  J Gen Intern Med       Date:  2010-04-13       Impact factor: 5.128

Review 6.  Development of new drugs in man: a review.

Authors:  I B Davies; I M Grind; A Pottage; P Turner
Journal:  J R Soc Med       Date:  1986-02       Impact factor: 5.344

7.  MRC trial of treatment of mild hypertension: principal results. Medical Research Council Working Party.

Authors: 
Journal:  Br Med J (Clin Res Ed)       Date:  1985-07-13

8.  Early treatment of unstable angina in the coronary care unit: a randomised, double blind, placebo controlled comparison of recurrent ischaemia in patients treated with nifedipine or metoprolol or both. Report of The Holland Interuniversity Nifedipine/Metoprolol Trial (HINT) Research Group.

Authors: 
Journal:  Br Heart J       Date:  1986-11

9.  Just-in-time information improved decision-making in primary care: a randomized controlled trial.

Authors:  Jessie McGowan; William Hogg; Craig Campbell; Margo Rowan
Journal:  PLoS One       Date:  2008-11-21       Impact factor: 3.240

10.  The Pediatric Obsessive-Compulsive Disorder Treatment Study II: rationale, design and methods.

Authors:  Jennifer B Freeman; Molly L Choate-Summers; Abbe M Garcia; Phoebe S Moore; Jeffrey J Sapyta; Muniya S Khanna; John S March; Edna B Foa; Martin E Franklin
Journal:  Child Adolesc Psychiatry Ment Health       Date:  2009-01-30       Impact factor: 3.033
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.