Literature DB >> 391377

Obesity may be due to a malfunctioning of brown fat.

J Himms-Hagen.   

Abstract

Recent basic research on the functioning of brown fat, a heat-producing tissue, has been fitted together with research on obesity to provide an exciting and challenging new approach to the study of the cause of obesity and could serve as a starting point for the development of new modes of treatment. Recent studies on brown adipose tissue have shown that a defect in this tissue is one probable cause of obesity.

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Mesh：

Year:  1979        PMID： 391377      PMCID： PMC1704532     

Source DB:  PubMed          Journal:  Can Med Assoc J        ISSN： 0008-4409            Impact factor:   8.262


  21 in total

1.  A mitochondrial defect in brown adipose tissue of the obese (ob/ob) mouse: reduced binding of purine nucleotides and a failure to respond to cold by an increase in binding.

Authors:  J Himms-Hagen; M Desautels
Journal:  Biochem Biophys Res Commun       Date:  1978-07-28       Impact factor: 3.575

2.  Fasting, feeding and regulation of the sympathetic nervous system.

Authors:  L Landsberg; J B Young
Journal:  N Engl J Med       Date:  1978-06-08       Impact factor: 91.245

3.  Reduced thermogenesis in obesity.

Authors:  R T Jung; P S Shetty; W P James; M A Barrand; B A Callingham
Journal:  Nature       Date:  1979-05-24       Impact factor: 49.962

4.  Effect of diet and cold exposure on norepinephrine turnover in pancreas and liver.

Authors:  J B Young; L Landsberg
Journal:  Am J Physiol       Date:  1979-05

5.  Comparison of microspheres and 86Rb+ as tracers of the distribution of cardiac output in rats indicates invalidity of 86Rb+-based measurements.

Authors:  D O Foster; M L Frydman
Journal:  Can J Physiol Pharmacol       Date:  1978-02       Impact factor: 2.273

6.  Roles of noradrenaline and protein synthesis in the cold-induced increase in purine nucleotide binding by rat brown adipose tissue mitochondria.

Authors:  M Desautels; J Himms-Hagen
Journal:  Can J Biochem       Date:  1979-06

7.  Brown-adipose-tissue mitochondria: photoaffinity labelling of the regulatory site of energy dissipation.

Authors:  G M Heaton; R J Wagenvoord; A Kemp; D G Nicholls
Journal:  Eur J Biochem       Date:  1978-01-16

8.  Increased purine nucleotide binding, altered polypeptide composition, and thermogenesis in brown adipose tissue mitochondria of cold-acclimated rats.

Authors:  M Desautels; G Zaror-Behrens; J Himms-Hagen
Journal:  Can J Biochem       Date:  1978-06

9.  An integrated view of the metabolic and genetic basis for obesity.

Authors:  W P James; P Trayhurn
Journal:  Lancet       Date:  1976-10-09       Impact factor: 79.321

10.  Thermoregulation and non-shivering thermogenesis in the genetically obese (ob/ob) mouse.

Authors:  P Trayhurn; W P James
Journal:  Pflugers Arch       Date:  1978-02-22       Impact factor: 3.657
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  20 in total

Review 1.  Anatomy of the adipose organ.

Authors:  S Cinti
Journal:  Eat Weight Disord       Date:  2000-09       Impact factor: 4.652

Review 2.  Does brown adipose tissue (BAT) have a role in the physiology or treatment of human obesity?

Authors:  J Himms-Hagen
Journal:  Rev Endocr Metab Disord       Date:  2001-10       Impact factor: 6.514

3.  Identification of brown adipose tissue in mice with fat-water IDEAL-MRI.

Authors:  Houchun H Hu; Daniel L Smith; Krishna S Nayak; Michael I Goran; Tim R Nagy
Journal:  J Magn Reson Imaging       Date:  2010-05       Impact factor: 4.813

4.  Variations in T(2)* and fat content of murine brown and white adipose tissues by chemical-shift MRI.

Authors:  Houchun H Hu; Catherine D G Hines; Daniel L Smith; Scott B Reeder
Journal:  Magn Reson Imaging       Date:  2012-01-13       Impact factor: 2.546

5.  Microcalorimetric measurements of heat production in brown adipocytes from control and cafeteria-fed rats.

Authors:  D G Clark; M Brinkman; S D Neville
Journal:  Biochem J       Date:  1986-04-15       Impact factor: 3.857

6.  BFIT, a unique acyl-CoA thioesterase induced in thermogenic brown adipose tissue: cloning, organization of the human gene and assessment of a potential link to obesity.

Authors:  S H Adams; C Chui; S L Schilbach; X X Yu; A D Goddard; J C Grimaldi; J Lee; P Dowd; S Colman; D A Lewin
Journal:  Biochem J       Date:  2001-11-15       Impact factor: 3.857

7.  Measurement of interscapular brown adipose tissue of mice in differentially housed temperatures by chemical-shift-encoded water-fat MRI.

Authors:  Daniel L Smith; Yongbin Yang; Houchun H Hu; Guihua Zhai; Tim R Nagy
Journal:  J Magn Reson Imaging       Date:  2013-04-11       Impact factor: 4.813

8.  Ephedrine activates brown adipose tissue in lean but not obese humans.

Authors:  A L Carey; M F Formosa; B Van Every; D Bertovic; N Eikelis; G W Lambert; V Kalff; S J Duffy; M H Cherk; B A Kingwell
Journal:  Diabetologia       Date:  2012-10-13       Impact factor: 10.122

9.  Identification and importance of brown adipose tissue in adult humans.

Authors:  Aaron M Cypess; Sanaz Lehman; Gethin Williams; Ilan Tal; Dean Rodman; Allison B Goldfine; Frank C Kuo; Edwin L Palmer; Yu-Hua Tseng; Alessandro Doria; Gerald M Kolodny; C Ronald Kahn
Journal:  N Engl J Med       Date:  2009-04-09       Impact factor: 91.245

10.  The effects of supplementation of the diet with highly palatable foods upon energy balance in the rat.

Authors:  G Armitage; G R Hervey; B J Rolls; E A Rowe; G Tobin
Journal:  J Physiol       Date:  1983-09       Impact factor: 5.182
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