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Literature DB >> 3911883

Pharmacokinetics of ceftazidime in elderly volunteers.

M LeBel, G Barbeau, F Vallee, M G Bergeron.

Abstract

The pharmacokinetics of ceftazidime after a 1-g bolus dose were studied in six elderly volunteers and 12 young subjects. Serum and urine samples were collected in serial order for 24 h and assayed by high-pressure liquid chromatography. The ceftazidime renal clearance was reduced in elderly subjects, a symptom related to normal aging of the kidneys. The decrease in volume of distribution in the elderly group may be explained by a reduction in total body water and an increase in fat tissue. Dosage adjustment is probably not necessary for otherwise healthy elderly patients requiring ceftazidime.

Entities: Chemical Species

Mesh：

Substances：
Ceftazidime
Creatinine

Year: 1985 PMID： 3911883 PMCID： PMC176368 DOI： 10.1128/AAC.28.5.713

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

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