Effect of clomiphene on the content of sterols and fatty acids in Saccharomyces cerevisiae.

During cultivation of Saccharomyces cerevisiae clomiphene regulates both quantitative and qualitative production of sterols and fatty acids as identified by gas chromatography and mass spectrometry. The content of sterols decreases to 75%, the production of fatty acids is comparable with that in the control. The occurrence of sterols increases; sterols with methyl group in position 4, without double bond in position 22 and with double bond in position 24(25) or 24(28) predominate. Among fatty acids shorter saturated and monoene acids are primarily produced, 2-hydroxy acids practically disappeared.