Literature DB >> 3910023

Genetically determined differences in liver alcohol dehydrogenase activity in male rats.

D W Crabb, T K Li.   

Abstract

Alcohol dehydrogenase (EC 1.1.1.1) activity was measured in liver extracts from one outbred and three inbred strains of rats. Strain-specific differences in enzyme activity were observed in the adult male rats. The differences appeared as the animals reached puberty. Studies on the enzyme purified from Sprague-Dawley and ACI rats indicate that the enzymes in these strains are identical and that the difference in activity found in liver extracts is due to differences in the amount of enzyme present. Genetic crosses between Sprague-Dawley and ACI rats suggest that the liver content of alcohol dehydrogenase is controlled by an autosomal regulatory locus with the characteristics of a temporal gene.

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Year:  1985        PMID： 3910023     DOI： 10.1007/bf00499942

Source DB:  PubMed          Journal:  Biochem Genet        ISSN： 0006-2928            Impact factor:   1.890


  13 in total

1.  Identification of a distinctive molecular form of alcohol dehydrogenase in human livers with high activity.

Authors:  T K Li; L J Magnes
Journal:  Biochem Biophys Res Commun       Date:  1975-03-03       Impact factor: 3.575

Review 2.  Acid hydrolases as models of genetic control.

Authors:  K Paigen
Journal:  Annu Rev Genet       Date:  1979       Impact factor: 16.830

3.  The kinetics of ethanol absorption and elimination in twins and supplementary repetitive experiments in singleton subjects.

Authors:  M Kopun; P Propping
Journal:  Eur J Clin Pharmacol       Date:  1977       Impact factor: 2.953

4.  Silver staining of proteins in polyacrylamide gels.

Authors:  W Wray; T Boulikas; V P Wray; R Hancock
Journal:  Anal Biochem       Date:  1981-11-15       Impact factor: 3.365

5.  Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs.

Authors:  M Kozak
Journal:  Nucleic Acids Res       Date:  1984-01-25       Impact factor: 16.971

6.  Quantitative correlation of ethanol elimination rates in vivo with liver alcohol dehydrogenase activities in fed, fasted and food-restricted rats.

Authors:  L Lumeng; W F Bosron; T K Li
Journal:  Biochem Pharmacol       Date:  1979-05-01       Impact factor: 5.858

7.  Purification and characterization of mouse alcohol dehydrogenase from two inbred strains that differ in total liver enzyme activity.

Authors:  D K Rex; W F Bosron; T K Li
Journal:  Biochem Genet       Date:  1984-02       Impact factor: 1.890

8.  Cloning and sequencing of cDNA encoding the complete mouse liver alcohol dehydrogenase.

Authors:  H J Edenberg; K Zhang; K Fong; W F Bosron; T K Li
Journal:  Proc Natl Acad Sci U S A       Date:  1985-04       Impact factor: 11.205

9.  Steady-state kinetic properties of purified rat liver alcohol dehydrogenase: application to predicting alcohol elimination rates in vivo.

Authors:  D W Crabb; W F Bosron; T K Li
Journal:  Arch Biochem Biophys       Date:  1983-07-01       Impact factor: 4.013

10.  Alcohol dehydrogenase isozymes in the mouse: genetic regulation, allelic variation among inbred strains and sex differences of liver and kidney A2 isozyme activity.

Authors:  R S Holmes; J A Duley; S Imai
Journal:  Anim Blood Groups Biochem Genet       Date:  1982
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