Literature DB >> 3900001

Localization of a new serine protease, ingobsin, in goblet cells in rat, pig and man.

S S Poulsen, E Nexø, P S Olsen, P Kirkegaard.   

Abstract

A serine protease, ingobsin, that cleaves Lys-x and Arg-x, has been purified from rat duodenal tissue. By immunohistochemical methods, the enzyme was localized in goblet cells in the small intestine of rat, pig, and man. The immunoreactive cells were most numerous in the proximal part of the intestine. In the electron microscope, the immunoreaction was localized mainly to the rough endoplasmic reticulum of the goblet cells and to the secretion being extruded from the cells.

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Year:  1985        PMID: 3900001     DOI: 10.1007/bf01003208

Source DB:  PubMed          Journal:  Histochem J        ISSN: 0018-2214


  8 in total

1.  The secretion and function of intestinal mucus.

Authors:  H W FLOREY
Journal:  Gastroenterology       Date:  1962-09       Impact factor: 22.682

2.  Renewal of chief cells and goblet cells in the small intestine as shown by radioautography after injection of thymidine-H3 into mice.

Authors:  C P LEBLOND; B MESSIER
Journal:  Anat Rec       Date:  1958-11

3.  Immunofluorescent localisation of enterokinase in human small intestine.

Authors:  J Hermon-Taylor; J Perrin; D A Grant; A Appleyard; M Bubel; A I Magee
Journal:  Gut       Date:  1977-04       Impact factor: 23.059

4.  Origin and renewal of goblet cells in the epithelium of the mouse small intestine.

Authors:  J Merzel; C P Leblond
Journal:  Am J Anat       Date:  1969-03

5.  Characterisation of a novel proteolytic enzyme localised to goblet cells in rat and man.

Authors:  E Nexø; S S Poulsen; S N Hansen; P Kirkegaard; P S Olsen
Journal:  Gut       Date:  1984-06       Impact factor: 23.059

6.  Histochemical demonstration of nonspecific esterase on the secretion of goblet cells in the guinea pig's small intestine.

Authors:  G Geyer; I Nietzold
Journal:  Acta Histochem       Date:  1968       Impact factor: 2.479

7.  Mucin degradation in human colon ecosystems. Evidence for the existence and role of bacterial subpopulations producing glycosidases as extracellular enzymes.

Authors:  L C Hoskins; E T Boulding
Journal:  J Clin Invest       Date:  1981-01       Impact factor: 14.808

8.  Mucin degradation in the intestine.

Authors:  F Ofosu; J Forstner; G Forstner
Journal:  Biochim Biophys Acta       Date:  1978-11-01
  8 in total
  1 in total

1.  Dipeptidyl peptidase (DPP) IV in rat organs. Comparison of immunohistochemistry and activity histochemistry.

Authors:  S Hartel; R Gossrau; C Hanski; W Reutter
Journal:  Histochemistry       Date:  1988
  1 in total

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