| Literature DB >> 3895067 |
Abstract
A review of the data from studies of oral contraceptives on coagulation and the fibrinolytic enzyme systems reveal an increase of a variety of coagulation factors. This is dose dependent and related to estrogens and appreciable above a dose of 0.5 micrograms of ethynylestradiol. Smaller amounts are less effective or not at all active. The mechanism of this increase is unknown. The pathophysiological significance is not yet clear. There is no available data that associate the increase of coagulation factors with disseminated intravascular coagulation. Conclusive evidence that low dose progesterone has any effect on the coagulation system is lacking.Entities:
Keywords: Biology; Blood Coagulation Effects; Cardiovascular Effects; Cerebrovascular Effects; Clinical Research; Contraception; Contraceptive Agents; Contraceptive Agents, Female; Contraceptive Methods--pharmacodynamics; Contraceptive Methods--side effects; Corpus Luteum Hormones; Diseases; Embolism; Estrogens; Family Planning; Fibrinolysis; Hematological Effects; Hemic System; Hormones; Menopause; Oral Contraceptives--pharmacodynamics; Oral Contraceptives--side effects; Physiology; Progesterone; Reproduction; Reproductive Control Agents; Research Methodology; Thromboembolism--etiology; Vascular Diseases
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Year: 1985 PMID： 3895067 DOI： 10.1097/00006254-198507000-00003
Source DB: PubMed Journal: Obstet Gynecol Surv ISSN： 0029-7828 Impact factor: 2.347