Literature DB >> 3894123

Plasma and skeletal muscle free amino acids in type I, insulin-treated diabetic subjects.

L Borghi, R Lugari, A Montanari, P Dall'Argine, G F Elia, V Nicolotti, I Simoni, A Parmeggiani, A Novarini, A Gnudi.   

Abstract

Insulin-dependent diabetes mellitus (IDDM) induces plasma amino acid (AA) abnormalities, including low alanine and high branched-chain (BCAA). While insulin treatment restores plasma AA pattern, proline, methionine, valine, isoleucine, and total BCAA remain elevated in skeletal muscle intracellular water. This suggests that the restoration of plasma AA concentrations is not a satisfactory index of recovered AA metabolism in IDDM.

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Year:  1985        PMID： 3894123     DOI： 10.2337/diab.34.8.812

Source DB:  PubMed          Journal:  Diabetes        ISSN： 0012-1797            Impact factor:   9.461


  7 in total

1.  Machine learning approach identifies meconium metabolites as potential biomarkers of neonatal hyperbilirubinemia.

Authors:  Shujuan Zeng; Zhangxing Wang; Peng Zhang; Zhaoqing Yin; Xunbin Huang; Xisheng Tang; Lindong Shi; Kaiping Guo; Ting Liu; Mingbang Wang; Huixian Qiu
Journal:  Comput Struct Biotechnol J       Date:  2022-04-02       Impact factor: 6.155

2.  Metabolic footprint of diabetes: a multiplatform metabolomics study in an epidemiological setting.

Authors:  Karsten Suhre; Christa Meisinger; Angela Döring; Elisabeth Altmaier; Petra Belcredi; Christian Gieger; David Chang; Michael V Milburn; Walter E Gall; Klaus M Weinberger; Hans-Werner Mewes; Martin Hrabé de Angelis; H-Erich Wichmann; Florian Kronenberg; Jerzy Adamski; Thomas Illig
Journal:  PLoS One       Date:  2010-11-11       Impact factor: 3.240

Review 3.  The role of skeletal muscle in the pathogenesis of altered concentrations of branched-chain amino acids (valine, leucine, and isoleucine) in liver cirrhosis, diabetes, and other diseases.

Authors:  M Holeček
Journal:  Physiol Res       Date:  2021-05-12       Impact factor: 1.881

Review 4.  The Critical Role of the Branched Chain Amino Acids (BCAAs) Catabolism-Regulating Enzymes, Branched-Chain Aminotransferase (BCAT) and Branched-Chain α-Keto Acid Dehydrogenase (BCKD), in Human Pathophysiology.

Authors:  Aikaterini Dimou; Vasilis Tsimihodimos; Eleni Bairaktari
Journal:  Int J Mol Sci       Date:  2022-04-05       Impact factor: 5.923

Review 5.  Branched-chain amino acids in health and disease: metabolism, alterations in blood plasma, and as supplements.

Authors:  Milan Holeček
Journal:  Nutr Metab (Lond)       Date:  2018-05-03       Impact factor: 4.169

Review 6.  Why Are Branched-Chain Amino Acids Increased in Starvation and Diabetes?

Authors:  Milan Holeček
Journal:  Nutrients       Date:  2020-10-11       Impact factor: 5.717

7.  Dual Effects of Beta-Hydroxy-Beta-Methylbutyrate (HMB) on Amino Acid, Energy, and Protein Metabolism in the Liver and Muscles of Rats with Streptozotocin-Induced Type 1 Diabetes.

Authors:  Milan Holeček; Melita Vodeničarovová; Radana Fingrová
Journal:  Biomolecules       Date:  2020-10-23
  7 in total

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