Literature DB >> 3893919

Spacer devices used with metered-dose inhalers. Breakthrough or gimmick?

P König.   

Abstract

In an effort to improve the delivery of a drug to the lungs, to correct problems of hand-lung discoordination, and to reduce local side effects such as oral candidiasis, a number of spacer devices have been developed to attach to metered-dose inhalers. Administration of bronchodilator drugs to patients with faulty techniques of inhalation has been improved with the addition of spacers. In adults and older children with a correct technique of inhaling bronchodilators, the spacer devices do not seem to have any advantage over the simple metered-dose inhalers. Young children (two to five years) can benefit from inhaled bronchodilators or corticosteroids by use of spacer devices with one-way valves. Older children and especially adults who suffer from dysphonia or thrush from inhaled corticosteroids can also benefit from spacers. In patients whose condition is well controlled with the usual inhaled doses of corticosteroids with no local side effects, spacer devices show promise, but more studies are needed.

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Year:  1985        PMID: 3893919     DOI: 10.1378/chest.88.2.276

Source DB:  PubMed          Journal:  Chest        ISSN: 0012-3692            Impact factor:   9.410


  21 in total

1.  Reducing electrostatic charge on spacer devices and bronchodilator response.

Authors:  J H Wildhaber; G W Waterer; G L Hall; Q A Summers
Journal:  Br J Clin Pharmacol       Date:  2000-09       Impact factor: 4.335

2.  Pediatrics: current therapy for asthma-new inhalants.

Authors:  W Richards
Journal:  West J Med       Date:  1986-08

Review 3.  The outpatient diagnosis and management of chronic obstructive pulmonary disease: pharmacotherapy, administration of supplemental oxygen, and smoking cessation techniques.

Authors:  R M Schapira; L F Reinke
Journal:  J Gen Intern Med       Date:  1995-01       Impact factor: 5.128

4.  Early lung absorption profile of non-CFC salbutamol via small and large volume plastic spacer devices.

Authors:  B J Lipworth; D J Clark
Journal:  Br J Clin Pharmacol       Date:  1998-07       Impact factor: 4.335

5.  Lung delivery of non-CFC salbutamol via small volume metal spacer and large volume plastic spacer devices compared with an open vent jet nebulizer.

Authors:  B J Lipworth; D J Clark
Journal:  Br J Clin Pharmacol       Date:  1998-02       Impact factor: 4.335

6.  Effect of electrostatic charge, flow, delay and multiple actuations on the in vitro delivery of salbutamol from different small volume spacers for infants.

Authors:  J H Wildhaber; S G Devadason; E Eber; M J Hayden; M L Everard; Q A Summers; P N LeSouëf
Journal:  Thorax       Date:  1996-10       Impact factor: 9.139

7.  Wheeze in childhood: is the spacer good enough?

Authors:  Veena Rajkumar; Barathi Rajendra; Choon How How; Seng Bin Ang
Journal:  Singapore Med J       Date:  2014-11       Impact factor: 1.858

8.  Equivalent pharmacokinetics of the active metabolite of ciclesonide with and without use of the AeroChamber Plus spacer for inhalation.

Authors:  Anton Drollmann; Ruediger Nave; Volker W Steinijans; Eugen Baumgärtner; Thomas D Bethke
Journal:  Clin Pharmacokinet       Date:  2006       Impact factor: 6.447

Review 9.  Spacer devices for metered dose inhalers.

Authors:  Stephen P Newman
Journal:  Clin Pharmacokinet       Date:  2004       Impact factor: 6.447

10.  Comparison of output particle size distributions from pressurized aerosols formulated as solutions or suspensions.

Authors:  R N Dalby; P R Byron
Journal:  Pharm Res       Date:  1988-01       Impact factor: 4.200

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