Literature DB >> 3893420

Lysosomal glycogen storage induced by Acarbose, a 1,4-alpha-glucosidase inhibitor.

R Geddes, J A Taylor.   

Abstract

The 1,4-alpha-glucosidase inhibitor. Acarbose, when injected intraperitoneally disturbs liver lysosome metabolism, causing distinct and persistent inhibition of the enzymes and acute disturbances of lysosomal glycogen metabolism. A feedback control mechanism appears to operate, affecting cytosolic carbohydrate metabolism. A model is suggested for the adult form of lysosomal storage disease. The biochemical effects closely resemble those occurring in glycogenosis type II (Pompe's disease), and these have been confirmed by electron microscopy.

Entities:  

Mesh：

Substances：

Year:  1985        PMID： 3893420      PMCID： PMC1144989          DOI： 10.1042/bj2280319

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  23 in total

1.  Molecular and metabolic heterogeneity of liver glycogen.

Authors:  R Geddes; G C Stratton
Journal:  Carbohydr Res       Date:  1977-08       Impact factor: 2.104

2.  The molecular size and shape of liver glycogen.

Authors:  R Geddes; J D Harvey; P R Wills
Journal:  Biochem J       Date:  1977-05-01       Impact factor: 3.857

3.  The influence of lysosomes on glycogen metabolism.

Authors:  R Geddes; G C Stratton
Journal:  Biochem J       Date:  1977-05-01       Impact factor: 3.857

4.  alpha-Glucosidase inhibitors. New complex oligosaccharides of microbial origin.

Authors:  D D Schmidt; W Frommer; B Junge; L Müller; W Wingender; E Truscheit; D Schäfer
Journal:  Naturwissenschaften       Date:  1977-10

5.  Staining tissue for light and electron microscopy by bridging metals with multidentate ligands.

Authors:  J S Hanker; C Deb; H L Wasserkrug; A M Seligman
Journal:  Science       Date:  1966-06-17       Impact factor: 47.728

6.  The spectrum and diagnosis of acid maltase deficiency.

Authors:  A G Engel; M R Gomez; M E Seybold; E H Lambert
Journal:  Neurology       Date:  1973-01       Impact factor: 9.910

7.  Post-mortem degradation of glycogen.

Authors:  R Geddes; K B Rapson
Journal:  FEBS Lett       Date:  1973-05-01       Impact factor: 4.124

8.  The structure of liver glycogen.

Authors:  N P Chee; R Geddes
Journal:  FEBS Lett       Date:  1977-02-01       Impact factor: 4.124

9.  Hydrodynamic properties of 2-mercaptoethanol-modified glycogen.

Authors:  R Geddes; J D Harvey; P R Wills
Journal:  Eur J Biochem       Date:  1977-12

10.  The apparent activity in vivo of the lysosomal pathway of glycogen catabolism in cultured human skin fibroblasts from patients with type III glycogen storage disease.

Authors:  D H Brown; L M Waindle; B I Brown
Journal:  J Biol Chem       Date:  1978-07-25       Impact factor: 5.157
View more
  2 in total

1.  Sensory Acceptance, Appetite Control and Gastrointestinal Tolerance of Yogurts Containing Coffee-Cascara Extract and Inulin.

Authors:  Maite Iriondo-DeHond; Amaia Iriondo-DeHond; Teresa Herrera; Adriana Maite Fernández-Fernández; Carlos Oscar S Sorzano; Eugenio Miguel; María Dolores Del Castillo
Journal:  Nutrients       Date:  2020-02-27       Impact factor: 5.717

2.  Biscuits with No Added Sugar Containing Stevia, Coffee Fibre and Fructooligosaccharides Modifies α-Glucosidase Activity and the Release of GLP-1 from HuTu-80 Cells and Serotonin from Caco-2 Cells after In Vitro Digestion.

Authors:  Nuria Martinez-Saez; Christina Maria Hochkogler; Veronika Somoza; Maria Dolores Del Castillo
Journal:  Nutrients       Date:  2017-07-04       Impact factor: 5.717
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.