Chemical and antigenic alterations of Candida albicans cell walls related to the action of amphotericin B sub-inhibitory doses.

Sub-inhibitory doses of amphotericin B led to Candida albicans cell wall modifications which involved peptidomannans. The amount of this product was reduced by a third, the decrease being due to mannans whose absolute and relative values fell whereas the amount of amino-acids increased. Concomitantly, the treated cells exhibited a loss in their immunological reactivity.