| Literature DB >> 3888432 |
J J Offerman, D T Sleijfer, N H Mulder, S Meijer, H Schraffordt Koops, A J Donker.
Abstract
On the assumption that hemodynamic changes in renal blood flow are the initial expression of cis-diamminedichloroplatinum (CDDP)-related nephrotoxicity, we treated patients with metastatic non-seminomatous testicular carcinoma during CDDP infusion with captopril. This angiotensin-converting enzyme inhibitor significantly attenuated the initial decrease in effective renal plasma flow and can probably be used to protect the kidneys against CDDP-induced nephrotoxicity.Entities:
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Year: 1985 PMID: 3888432 DOI: 10.1007/bf00258130
Source DB: PubMed Journal: Cancer Chemother Pharmacol ISSN: 0344-5704 Impact factor: 3.333