Literature DB >> 1819725

Effect of platelet-activating factor antagonist BN 52063 on the nephrotoxicity of cisplatin.

O F dos Santos1, M A Boim, E J Barros, E Pirotzky, P Braquet, N Schor.   

Abstract

Cisplatin (DDP) is an effective anticancer agent that has been successfully applied against various solid tumors. However, DDP commonly causes nephrotoxicity. We observed that DDP led to significant alterations in renal microcirculation when administered to Munich-Wistar rats, with a concomitant decrease in single nephron glomerular filtration rate due to reduction in glomerular plasma flow and transcapillary hydraulic pressure difference. BN 52063, a platelet-activating factor antagonist, caused a striking change in acute renal failure induced by DDP leading toward normalization of all parameters of renal function. The results suggest that BN 52063 could be used as a novel drug to control DDP nephrotoxicity.

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Year:  1991        PMID： 1819725     DOI： 10.1007/BF02536558

Source DB:  PubMed          Journal:  Lipids        ISSN： 0024-4201            Impact factor:   1.880


  22 in total

1.  [A simple colorimetric method of inulin determination in renal clearance studies on metabolically normal subjects and diabetics].

Authors:  J FUHR; J KACZMARCZYK; C D KRUTTGEN
Journal:  Klin Wochenschr       Date:  1955-08-01

2.  CIS-Dichlorodiammineplatinum(II) in the treatment of epidermoid carcinoma of the head and neck.

Authors:  R E Wittes; E Cvitkovic; J Shah; F P Gerold; E W Strong
Journal:  Cancer Treat Rep       Date:  1977 May-Jun

3.  Determination of serum protein concentration in nanoliter blood samples using fluorescamine or 9-phthalaldehyde.

Authors:  J W Viets; W M Deen; J L Troy; B M Brenner
Journal:  Anal Biochem       Date:  1978-08-01       Impact factor: 3.365

4.  Atrial natriuretic factor increases glomerular filtration rate in the experimental acute renal failure induced by cisplatin.

Authors:  G Capasso; P Anastasio; D Giordano; L Albarano; A Rufolo; N G De Santo
Journal:  Adv Exp Med Biol       Date:  1987       Impact factor: 2.622

5.  Acute and subacute hemodynamic and tubular effect of cisplatin in dogs.

Authors:  G Daugaard; U Abildgaard; N H Holstein-Rathlou; O Amtorp; P P Leyssac
Journal:  Contrib Nephrol       Date:  1987       Impact factor: 1.580

Review 6.  The role of cis-platinum in solid-tumor therapy.

Authors:  L H Einhorn; S D Williams
Journal:  N Engl J Med       Date:  1979-02-08       Impact factor: 91.245

7.  Cis-diamminedichlorplatinum-induced acute renal failure in the rat.

Authors:  S Chopra; J S Kaufman; T W Jones; W K Hong; M K Gehr; R J Hamburger; W Flamenbaum; B F Trump
Journal:  Kidney Int       Date:  1982-01       Impact factor: 10.612

8.  Reduced renal blood flow in early cisplatin-induced acute renal failure in the rat.

Authors:  J A Winston; R Safirstein
Journal:  Am J Physiol       Date:  1985-10

9.  Effect of sodium thiosulfate on cis-dichlorodiammineplatinum(II) toxicity and antitumor activity in L1210 leukemia.

Authors:  S B Howell; R Taetle
Journal:  Cancer Treat Rep       Date:  1980 Apr-May

10.  Mechanisms of action of various hormones and vasoactive substances on glomerular ultrafiltration in the rat.

Authors:  N Schor; I Ichikawa; B M Brenner
Journal:  Kidney Int       Date:  1981-10       Impact factor: 10.612
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  1 in total

Review 1.  The Rationale for "Laser-Induced Thermal Therapy (LITT) and Intratumoral Cisplatin" Approach for Cancer Treatment.

Authors:  Renan Vieira de Brito; Marília Wellichan Mancini; Marcel das Neves Palumbo; Luis Henrique Oliveira de Moraes; Gerson Jhonatan Rodrigues; Onivaldo Cervantes; Joel Avram Sercarz; Marcos Bandiera Paiva
Journal:  Int J Mol Sci       Date:  2022-05-25       Impact factor: 6.208
  1 in total

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