Novel thiazolidine-2,4-dione-4-thiosemicarbazone and 4-[(3,4-diaryl-3H-thiazol-2-yl)azo]thiazolidin-2-one derivatives: synthesis and evaluation for antimicrobial and anticancer properties.

Two novel series of 3-benzylthiazolidine-2,4-dione-4-thiosemicarbazones (V - IX) and 3-benzyl-4-[(3,4-diaryl-3H-thiazol-2-yl)azo]thiazolidin-2-on es (X - XXII) were synthesized as potential antimicrobial and anticancer agents. The products were found to be inactive against a variety of microorganisms and the preliminary antileukemic evaluation of some representative compounds against P 388 lymphocytic leukemia indicated insignificant activity.