Literature DB >> 3878755

A reinvestigation of the cross-reactivity between Klebsiella and HLA-B27 in the aetiology of ankylosing spondylitis.

K Georgopoulos, W C Dick, J A Goodacre, R H Pain.   

Abstract

The existence of cross-reactivity between Klebsiella antigens and cells from donors who are HLA-B27 positive and exhibit ankylosing spondylitis (AS) has been reinvestigated. Cells and antisera from different laboratories have been tested together using simultaneously microcytoxicity, chromium release and enzyme linked immunosorbent assays (ELISA). No reproducible interaction has been found. Mitogenic stimulation did not induce cross-reactivity and 'transformation' of B27+AS- cells by Klebsiella culture supernatants failed. Two transformed cell lines from B27+ AS+ donors exhibited specific cross reaction with two anti-Klebsiella antisera but only by chromium release. Immunoprecipitation with these cells and antisera showed the absence of any AS+ -specific antigen. It is concluded that the involvement of Klebsiella in ankylosing spondylitis through simple immunological cross-reactivity or through interaction with HLA-B27 is unlikely.

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Year:  1985        PMID： 3878755      PMCID： PMC1577472     

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN： 0009-9104            Impact factor:   4.330


  17 in total

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Journal:  Annu Rev Med       Date:  1977       Impact factor: 13.739

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Journal:  Lancet       Date:  1979-03-31       Impact factor: 79.321

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Authors:  F C Grumet
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Journal:  Ann Rheum Dis       Date:  1978-04       Impact factor: 19.103

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Authors:  A F Geczy; K Alexander; H V Bashir; J Edmonds
Journal:  Nature       Date:  1980-02-21       Impact factor: 49.962

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Authors:  R Ebringer; D Cooke; D R Cawdell; P Cowling; A Ebringer
Journal:  Rheumatol Rehabil       Date:  1977-08

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Authors:  R W Ebringer; D R Cawdell; P Cowling; A Ebringer
Journal:  Ann Rheum Dis       Date:  1978-04       Impact factor: 19.103

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Authors:  J Welsh; H Avakian; P Cowling; A Ebringer; P Wooley; G Panayi; R Ebringer
Journal:  Br J Exp Pathol       Date:  1980-02
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  6 in total

1.  Lack of correlation between HLA-B27 like antigenic epitopes on Shigella flexneri and the occurrence of reactive arthritis.

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Journal:  Clin Exp Immunol       Date:  1986-09       Impact factor: 4.330

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Authors:  N T Baerlecken
Journal:  Z Rheumatol       Date:  2017-08       Impact factor: 1.372

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Authors:  J Neumüller; M Fischer; R Eberl
Journal:  Rheumatol Int       Date:  1993       Impact factor: 2.631

Review 4.  HLA-B27 associated spondyloarthropathy, an autoimmune disease based on crossreactivity between bacteria and HLA-B27?

Authors:  J H Ringrose
Journal:  Ann Rheum Dis       Date:  1999-10       Impact factor: 19.103

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Authors:  I L MacLean; J R Archer; M I Cawley; B L Kidd; B P O'Hara; F S Pegley; P W Thompson
Journal:  Ann Rheum Dis       Date:  1992-01       Impact factor: 19.103

6.  Decreased frequencies of circulating follicular helper T cell counterparts and plasmablasts in ankylosing spondylitis patients Naïve for TNF blockers.

Authors:  María-Belén Bautista-Caro; Irene Arroyo-Villa; Concepción Castillo-Gallego; Eugenio de Miguel; Diana Peiteado; Chamaida Plasencia-Rodríguez; Alejandro Villalba; Paloma Sánchez-Mateos; Amaya Puig-Kröger; Emilio Martín-Mola; María-Eugenia Miranda-Carús
Journal:  PLoS One       Date:  2014-09-09       Impact factor: 3.240
  6 in total

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