Literature DB >> 3876766

Chromosomal localization of the human alpha 1-antitrypsin gene (PI) to 14q31-32.

W T Schroeder, M F Miller, S L Woo, G F Saunders.   

Abstract

In situ hybridization of a recombinant cDNA probe containing the human alpha 1-antitrypsin gene to metaphase chromosomes demonstrated significant hybridization to chromosomal segment 14q31-32. A high percentage of cells analyzed (31%) displayed labeling on chromosome 14. Of all labeled sites on chromosome 14, 60% were found on segment 14q31-32. These results refine the previous assignment of the human alpha 1-antitrypsin gene to segment 14q24.1-32.1.

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Year:  1985        PMID： 3876766      PMCID： PMC1684682     

Source DB:  PubMed          Journal:  Am J Hum Genet        ISSN： 0002-9297            Impact factor:   11.025


  10 in total

1.  Complete sequence of the cDNA for human alpha 1-antitrypsin and the gene for the S variant.

Authors:  G L Long; T Chandra; S L Woo; E W Davie; K Kurachi
Journal:  Biochemistry       Date:  1984-10-09       Impact factor: 3.162

Review 2.  Hybridization of nucleic acids immobilized on solid supports.

Authors:  J Meinkoth; G Wahl
Journal:  Anal Biochem       Date:  1984-05-01       Impact factor: 3.365

3.  Genes for immunoglobulin heavy chains and for alpha 1-antitrypsin are localized to specific regions of chromosome 14q.

Authors:  D W Cox; V D Markovic; I E Teshima
Journal:  Nature       Date:  1982-06-03       Impact factor: 49.962

4.  Localization of single copy DNA sequences of G-banded human chromosomes by in situ hybridization.

Authors:  M E Harper; G F Saunders
Journal:  Chromosoma       Date:  1981       Impact factor: 4.316

5.  Sequence homology and structural comparison between the chromosomal human alpha 1-antitrypsin and chicken ovalbumin genes.

Authors:  M Leicht; G L Long; T Chandra; K Kurachi; V J Kidd; M Mace; E W Davie; S L Woo
Journal:  Nature       Date:  1982-06-24       Impact factor: 49.962

6.  Construction and characterization of new cloning vehicles. II. A multipurpose cloning system.

Authors:  F Bolivar; R L Rodriguez; P J Greene; M C Betlach; H L Heyneker; H W Boyer; J H Crosa; S Falkow
Journal:  Gene       Date:  1977       Impact factor: 3.688

7.  Assignment of the alpha 1-antitrypsin gene and a sequence-related gene to human chromosome 14 by molecular hybridization.

Authors:  E C Lai; F T Kao; M L Law; S L Woo
Journal:  Am J Hum Genet       Date:  1983-05       Impact factor: 11.025

8.  The ovalbumin gene: alleles created by mutations in the intervening sequences of the natural gene.

Authors:  E C Lai; S L Woo; A Dugaiczyk; B W O'Malley
Journal:  Cell       Date:  1979-01       Impact factor: 41.582

Review 9.  High-resolution chromosome analysis in clinical medicine.

Authors:  J J Yunis; M E Chandler
Journal:  Prog Clin Pathol       Date:  1978

10.  alpha 1-antitrypsin deficiency detection by direct analysis of the mutation in the gene.

Authors:  V J Kidd; R B Wallace; K Itakura; S L Woo
Journal:  Nature       Date:  1983 Jul 21-27       Impact factor: 49.962
  10 in total
  20 in total

1.  Alpha-1 antitrypsin phenotypes in patients with Klinefelter's syndrome.

Authors:  Ruth Mikelsaar; Jelena Lissitsina; Kristo Ausmees; Margus Punab; Paul Korrovits; Eve Vaidla
Journal:  J Genet       Date:  2010-12       Impact factor: 1.166

2.  Genetic studies on a new deficiency gene (PI*Ztun) at the PI locus.

Authors:  D B Whitehouse; C M Abbott; J U Lovegrove; I McIntosh; C J McMahon; G Mieli-Vergani; A P Mowat; D A Hopkinson
Journal:  J Med Genet       Date:  1989-12       Impact factor: 6.318

3.  Rare case of eosinophilic granulomatosis with polyangiitis in two patients with α-1-antitrypsin deficiency (PiSZ).

Authors:  Jordan Maureen Moxey; Emma Victoria Low; Alice Margaret Turner
Journal:  BMJ Case Rep       Date:  2016-04-26

4.  Neonatal screening for alpha-1-antitrypsin deficiency.

Authors:  J Kimpen; E Bosmans; J Raus
Journal:  Eur J Pediatr       Date:  1988-10       Impact factor: 3.183

5.  The human corticosteroid binding globulin gene is located on chromosome 14q31-q32.1 near two other serine protease inhibitor genes.

Authors:  G E Seralini; D Bérubé; R Gagné; G L Hammond
Journal:  Hum Genet       Date:  1990-11       Impact factor: 4.132

6.  RFLP for a gene-related sequence of alpha 1-antitrypsin (AAT).

Authors:  I Hodgson; N Kalsheker
Journal:  Nucleic Acids Res       Date:  1986-08-26       Impact factor: 16.971

7.  Array CGH defined interstitial deletion on chromosome 14: a new case.

Authors:  Maria Piccione; Vincenzo Antona; Valeria Scavone; Michela Malacarne; Mauro Pierluigi; Marina Grasso; Giovanni Corsello
Journal:  Eur J Pediatr       Date:  2010-01-21       Impact factor: 3.183

Review 8.  Gene Therapy for Alpha-1 Antitrypsin Deficiency Lung Disease.

Authors:  Maria J Chiuchiolo; Ronald G Crystal
Journal:  Ann Am Thorac Soc       Date:  2016-08

9.  Alpha 1-antitrypsin gene polymorphism related to respiratory system disease.

Authors:  M Buraczynska; D Schött; A J Hanzlik; B Höltmann; W T Ulmer
Journal:  Klin Wochenschr       Date:  1987-07-15

10.  Gene targeted therapeutics for liver disease in alpha-1 antitrypsin deficiency.

Authors:  Caitriona McLean; Catherine M Greene; Noel G McElvaney
Journal:  Biologics       Date:  2009-07-13
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