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Literature DB >> 3876507

In vivo mutant frequency rises among breast cancer patients after exposure to high doses of gamma-radiation.

Abstract

Human in vivo mutant frequencies can be measured by cloning freshly isolated lymphocytes in selective media containing 6-thioguanine (TG). This method was applied to monitoring environmental mutagenesis, by studying lymphocytes separated from peripheral blood of 12 cancer patients undergoing radiotherapy. Before therapy, cancer patients had an average 8.6 X 10(-6) mutants/cell, compared to 2.4 X 10(-6) mutants/cell for heart patients and 1.1 X 10(-6) mutants/cell for healthy controls. After exposure of cancer patients to 50 Gy of gamma-radiation delivered to the treated area, or an estimated 4 Gy received by each lymphocyte, patients averaged 36.8 X 10(-6) mutants/viable cell.

Entities: Chemical Disease Species

Mesh：

Year: 1985 PMID： 3876507 DOI： 10.1016/0027-5107(85)90051-x

Source DB: PubMed Journal: Mutat Res ISSN： 0027-5107 Impact factor: 2.433

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Cited

8 in total

1. Molecular characterization of 15 rearrangements among 90 human in vivo somatic mutants shows that deletions predominate.

Authors: W E Bradley; J L Gareau; A M Seifert; K Messing
Journal: Mol Cell Biol Date: 1987-02 Impact factor: 4.272

2. Selection against blood cells deficient in hypoxanthine phosphoribosyltransferase (HPRT) in Lesch-Nyhan heterozygotes occurs at the level of multipotent stem cells.

Authors: M Hakoda; Y Hirai; M Akiyama; H Yamanaka; C Terai; N Kamatani; S Kashiwazaki
Journal: Hum Genet Date: 1995-12 Impact factor: 4.132

In vivo mutant frequency rises among breast cancer patients after exposure to high doses of gamma-radiation.

1. Molecular characterization of 15 rearrangements among 90 human in vivo somatic mutants shows that deletions predominate.

2. Selection against blood cells deficient in hypoxanthine phosphoribosyltransferase (HPRT) in Lesch-Nyhan heterozygotes occurs at the level of multipotent stem cells.

3. Increased frequency of in vivo hprt gene-mutated T cells in the peripheral blood of patients with systemic sclerosis.

Review 4. In vivo mutations in human blood cells: biomarkers for molecular epidemiology.

5. Mutagenesis after cancer therapy.

Review 6. Human somatic mutation assays as biomarkers of carcinogenesis.

7. Somatic cell gene mutations in humans: biomarkers for genotoxicity.

8. Somatic mutation in peripheral lymphocytes of former workers at the Okunojima poison gas factory.