Literature DB >> 3873977

MPTP primate model of Parkinson's disease: a mechanographic and electromyographic study.

D Doudet, C Gross, P Lebrun-Grandie, B Bioulac.   

Abstract

Movement parameters and electromyographic (EMG) studies were carried out in two macaque monkeys performing a rapid arm movement before and after administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Hypokinesia and rigidity were seen after repeated doses. Disturbances in both movements and EMG activity were similar to those reported in Parkinsonian patients.

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Year:  1985        PMID： 3873977     DOI： 10.1016/0006-8993(85)90294-x

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  9 in total

1.  Modifications of precentral cortex discharge and EMG activity in monkeys with MPTP-induced lesions of DA nigral neurons.

Authors:  D J Doudet; C Gross; M Arluison; B Bioulac
Journal:  Exp Brain Res       Date:  1990       Impact factor: 1.972

2.  Modeling Parkinson's disease in primates: The MPTP model.

Authors:  Gregory Porras; Qin Li; Erwan Bezard
Journal:  Cold Spring Harb Perspect Med       Date:  2012-03       Impact factor: 6.915

3.  MPTP Induces Systemic Parkinsonism in Middle-Aged Cynomolgus Monkeys: Clinical Evolution and Outcomes.

Authors:  Feng Yue; Sien Zeng; Rongping Tang; Guoxian Tao; Piu Chan
Journal:  Neurosci Bull       Date:  2016-10-03       Impact factor: 5.203

4.  6-18F-L-dopa imaging of the dopamine neostriatal system in normal and clinically normal MPTP-treated rhesus monkeys.

Authors:  D J Doudet; H Miyake; R T Finn; C A McLellan; T G Aigner; R Q Wan; H R Adams; R M Cohen
Journal:  Exp Brain Res       Date:  1989       Impact factor: 1.972

5.  MPTP induced hemiparkinsonism in monkeys: behavioral, mechanographic, electromyographic and immunohistochemical studies.

Authors:  A Benazzouz; C Gross; J Dupont; B Bioulac
Journal:  Exp Brain Res       Date:  1992       Impact factor: 1.972

Review 6.  Induced pluripotent stem cells and Parkinson's disease: modelling and treatment.

Authors:  Xiaoyun Xu; Jinsha Huang; Jie Li; Ling Liu; Chao Han; Yan Shen; Guoxin Zhang; Haiyang Jiang; Zhicheng Lin; Nian Xiong; Tao Wang
Journal:  Cell Prolif       Date:  2016-01-08       Impact factor: 6.831

7.  Grafting of fetal substantia nigra to striatum reverses behavioral deficits induced by MPTP in primates: a comparison with other types of grafts as controls.

Authors:  J R Taylor; J D Elsworth; R H Roth; J R Sladek; T J Collier; D E Redmond
Journal:  Exp Brain Res       Date:  1991       Impact factor: 1.972

8.  Fucoidan Protects Dopaminergic Neurons by Enhancing the Mitochondrial Function in a Rotenone-induced Rat Model of Parkinson's Disease.

Authors:  Li Zhang; Junwei Hao; Yan Zheng; Ruijun Su; Yajin Liao; Xiaoli Gong; Limin Liu; Xiaomin Wang
Journal:  Aging Dis       Date:  2018-08-01       Impact factor: 6.745

9.  α-Synuclein Induces the GSK-3-Mediated Phosphorylation and Degradation of NURR1 and Loss of Dopaminergic Hallmarks.

Authors:  Ángel Juan García-Yagüe; Isabel Lastres-Becker; Leonidas Stefanis; Demetrios K Vassilatis; Antonio Cuadrado
Journal:  Mol Neurobiol       Date:  2021-10-05       Impact factor: 5.590
  9 in total

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