| Literature DB >> 3872459 |
V Jonas, C R Lin, E Kawashima, D Semon, L W Swanson, J J Mermod, R M Evans, M G Rosenfeld.
Abstract
Two mRNAs generated as a consequence of alternative RNA processing events in expression of the human calcitonin gene encode the protein precursors of either calcitonin or calcitonin gene-related peptide (CGRP). Both calcitonin and CGRP RNAs and their encoded peptide products are expressed in the human pituitary and in medullary thyroid tumors. On the basis of sequence comparison, it is suggested that both the calcitonin and CGRP exons arose from a common primordial sequence, suggesting that duplication and rearrangement events are responsible for the generation of this complex transcription unit.Entities:
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Year: 1985 PMID： 3872459 PMCID： PMC397471 DOI： 10.1073/pnas.82.7.1994
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205