Literature DB >> 3872188

Immunoregulatory effects of interferon-alpha. I. Interferon-alpha inhibits in vitro antibody synthesis by normal human lymphocytes.

B K Pelton, A M Denman.   

Abstract

The effects of human interferon-alpha (IFN-alpha) on in vitro synthesis of specific anti-influenza virus antibody were measured in cultures of peripheral blood lymphocytes from normal donors. IFN-alpha suppressed antibody synthesis in a time and dose related manner. This suppression was also produced by monoclonal antibody purified IFN-alpha and was blocked by anti-IFN-alpha antibody. However antibody induced by a combination of antigen and 'B cell helper supernatant' was not suppressed indicating that IFN-alpha inhibits the initial events in antibody synthesis but does not affect cells committed to antibody production.

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Year:  1985        PMID： 3872188      PMCID： PMC1577144     

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN： 0009-9104            Impact factor:   4.330


  26 in total

Review 1.  Antitumor effects of interferon.

Authors:  I Gresser; M G Tovey
Journal:  Biochim Biophys Acta       Date:  1978-10-27

2.  Time and dosage dependence of immunoenhancement by murine type II interferon preparations.

Authors:  G Sonnenfeld; A D Mandel; T C Merigan
Journal:  Cell Immunol       Date:  1978-10       Impact factor: 4.868

3.  A monoclonal antibody for large-scale purification of human leukocyte interferon.

Authors:  D S Secher; D C Burke
Journal:  Nature       Date:  1980-06-12       Impact factor: 49.962

4.  Effect of interferon alpha on pokeweed mitogen-induced differentiation of human peripheral blood b lymphocytes.

Authors:  Y S Choi; K H Lim; F K Sanders
Journal:  Cell Immunol       Date:  1981-10       Impact factor: 4.868

5.  Specific in vitro antibody response to influenza virus by human blood lymphocytes.

Authors:  R E Callard
Journal:  Nature       Date:  1979-12-13       Impact factor: 49.962

6.  Spontaneous release of a factor with properties of T cell growth factor from a continuous line of primate tumor T cells.

Authors:  H Rabin; R F Hopkins; F W Ruscetti; R H Neubauer; R L Brown; T G Kawakami
Journal:  J Immunol       Date:  1981-11       Impact factor: 5.422

7.  Immune interferon in the circulation of patients with autoimmune disease.

Authors:  J J Hooks; H M Moutsopoulos; S A Geis; N I Stahl; J L Decker; A L Notkins
Journal:  N Engl J Med       Date:  1979-07-05       Impact factor: 91.245

8.  Interferon acts directly on human B lymphocytes to modulate immunoglobulin synthesis.

Authors:  B Härfast; J R Huddlestone; P Casali; T C Merigan; M B Oldstone
Journal:  J Immunol       Date:  1981-11       Impact factor: 5.422

9.  Effect of virus-induced interferon on the antibody response of suckling and adult mice.

Authors:  F Vignaux; I Gresser; W H Fridman
Journal:  Eur J Immunol       Date:  1980-10       Impact factor: 5.532

10.  Induction and kinetics of natural killer cells in humans following interferon therapy.

Authors:  J R Huddlestone; T C Merigan; M B Oldstone
Journal:  Nature       Date:  1979-11-22       Impact factor: 49.962
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  3 in total

1.  The effect of interferon-alpha on the ecto 5'-nucleotidase of human lymphoblastoid B-cell lines depends on the class of immunoglobulin secreted.

Authors:  S M Johnson
Journal:  Immunology       Date:  1991-09       Impact factor: 7.397

2.  Modulation of the defective natural killer activity seen in thalassaemia major with desferrioxamine and alpha-interferon.

Authors:  A N Akbar; P A Fitzgerald-Bocarsly; P J Giardina; M W Hilgartner; R W Grady
Journal:  Clin Exp Immunol       Date:  1987-11       Impact factor: 4.330

3.  Effects of interferons on human B-cell differentiation in vitro.

Authors:  S Y Kim; H Stoetter; H Heimpel
Journal:  Korean J Intern Med       Date:  1987-07       Impact factor: 2.884
  3 in total

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