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Literature DB >> 3867330

Cilastatin does not alter superoxide dismutase activity.

Abstract

Cilastatin inhibits dehydropeptidase-I, a zinc metaloenzyme that metabolizes imipenem. Because zinc stabilizes the mammalian superoxide dismutase, we postulated that cilastatin would also inhibit the dismutase. Cilastatin concentrations at levels threefold higher than those expected in urine, however, did not inhibit the superoxide dismutase activity.

Entities: Chemical Gene Species

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Year: 1985 PMID： 3867330 PMCID： PMC176359 DOI： 10.1128/AAC.28.5.691

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

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References

13 in total

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Authors: R E Heikkila; F S Cabbat; G Cohen
Journal: J Biol Chem Date: 1976-04-10 Impact factor: 5.157

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Authors: J M McCord; I Fridovich
Journal: J Biol Chem Date: 1969-11-25 Impact factor: 5.157

3. Urinary recovery of N-formimidoyl thienamycin (MK0787) as affected by coadministration of N-formimidoyl thienamycin dehydropeptidase inhibitors.

Authors: S R Norrby; K Alestig; B Björnegård; L A Burman; F Ferber; J L Huber; K H Jones; F M Kahan; J S Kahan; H Kropp; M A Meisinger; J G Sundelof
Journal: Antimicrob Agents Chemother Date: 1983-02 Impact factor: 5.191

4. Comparative in vitro activity of N-formimidoyl thienamycin against gram-positive and gram-negative aerobic and anaerobic species and its beta-lactamase stability.

Authors: H C Neu; P Labthavikul
Journal: Antimicrob Agents Chemother Date: 1982-01 Impact factor: 5.191

Cilastatin does not alter superoxide dismutase activity.

1. In vivo inhibition of superoxide dismutase in mice by diethyldithiocarbamate.

2. Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein).

3. Urinary recovery of N-formimidoyl thienamycin (MK0787) as affected by coadministration of N-formimidoyl thienamycin dehydropeptidase inhibitors.

4. Comparative in vitro activity of N-formimidoyl thienamycin against gram-positive and gram-negative aerobic and anaerobic species and its beta-lactamase stability.

5. Structural and biochemical adaptive changes in rat lungs after exposure to hypoxia.

6. Imipenem versus moxalactam in the treatment of serious infections.

7. Pharmacokinetics of imipenem and cilastatin in patients with cystic fibrosis.

8. Mechanism for the potentiation of oxygen toxicity by disulfiram.

9. Imipenem therapy of Pseudomonas aeruginosa and other serious bacterial infections.

10. Metabolism of thienamycin and related carbapenem antibiotics by the renal dipeptidase, dehydropeptidase.