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Literature DB >> 3866502

Measurement of meperidine-induced respiratory depression using a new non-invasive technique.

E V Hersh, P J Desjardins, M Simpser, C Dadzie.

Abstract

Inductive plethysmography was used to assess the magnitude and duration of respiratory depression caused by doses of meperidine commonly administered during dental intravenous sedation. Minute volume measurements exhibited a high degree of accuracy when compared to simultaneous spirometry. Intravenously administered meperidine 25 mg/70 kg and 50 mg/70 kg both caused a significant shift to the right in their respective ventilatory-pco(2) response curves. The magnitude and duration of this respiratory depression was dose related. Even relatively low doses of meperidine used in dental intravenous sedation cause respiratory depression.

Entities: Chemical Disease

Mesh：

Substances：
Meperidine

Year: 1985 PMID： 3866502 PMCID： PMC2175416

Source DB: PubMed Journal: Anesth Prog ISSN： 0003-3006

15 in total

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Journal: Clin Pharmacol Ther Date: 1976-06 Impact factor: 6.875

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Journal: J Oral Surg Date: 1974-10

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Journal: N Z Dent J Date: 1967-10

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Authors: J M Goodson; P A Moore
Journal: J Am Dent Assoc Date: 1983-08 Impact factor: 3.634

5. Respiratory effects of butorphanol and pethidine.

Authors: T Kallos; F S Caruso
Journal: Anaesthesia Date: 1979 Jul-Aug Impact factor: 6.955

Review 6. Assessment of the effects of drugs on respiration.

Authors: C Jordan
Journal: Br J Anaesth Date: 1982-07 Impact factor: 9.166

7. Postural changes in rib cage and abdominal volume-motion coefficients and their effect on the calibration of a respiratory inductance plethysmograph.

Authors: P V Zimmerman; S J Connellan; H C Middleton; M V Tabona; M D Goldman; N Pride
Journal: Am Rev Respir Dis Date: 1983-02

Review 8. Hypoxic encephalopathy after the administration of alphaprodine hydrochloride.

Authors: D M Okuji
Journal: J Am Dent Assoc Date: 1981-07 Impact factor: 3.634

9. The effect of morphine and of meperidine (dolantin, demerol) upon the respiratory response of normal men to low concentrations of inspired carbon dioxide.

Authors: H H LOESCHCKE; A SWEEL; R H KOUGH; C J LAMBERTSEN
Journal: J Pharmacol Exp Ther Date: 1953-07 Impact factor: 4.030