Literature DB >> 6095101

Isolation of cDNA clones encoding the 20K T3 glycoprotein of human T-cell receptor complex.

P van den Elsen, B A Shepley, J Borst, J E Coligan, A F Markham, S Orkin, C Terhorst.   

Abstract

The complete amino acid sequence of one of the polypeptide chains of the human T3/T-cell receptor complex, the T3 glycoprotein (T3-delta-chain) of relative molecular mass 20,000, was deduced from cDNA clones derived from HPB-ALL cells and a human T-cell clone. Inspection of the 171-amino acid sequence reveals a signal peptide, a 79-amino acid extracellular domain, one transmembrane region and a 44-amino acid intracellular domain which show no sequence homology with members of the T-cell receptor/immunoglobulin/MHC multi-gene family. The T3 delta-chain is coded for by a single-copy gene the expression of which is restricted to T lymphocytes in humans and mice.

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Year:  1984        PMID： 6095101     DOI： 10.1038/312413a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  76 in total

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4.  Primary structure and ontogeny of an avian CD3 transcript.

Authors:  A Bernot; C Auffray
Journal:  Proc Natl Acad Sci U S A       Date:  1991-03-15       Impact factor: 11.205

5.  Localization of an ataxia-telangiectasia locus to a 3-cM interval on chromosome 11q23: linkage analysis of 111 families by an international consortium.

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Journal:  Am J Hum Genet       Date:  1991-12       Impact factor: 11.025

6.  T cell receptors and immunoregulation.

Authors:  L S Rayfield
Journal:  J R Soc Med       Date:  1985-12       Impact factor: 5.344

7.  Stimulation of T cells through the CD3/T-cell receptor complex: role of cytoplasmic calcium, protein kinase C translocation, and phosphorylation of pp60c-src in the activation pathway.

Authors:  J A Ledbetter; L E Gentry; C H June; P S Rabinovitch; A F Purchio
Journal:  Mol Cell Biol       Date:  1987-02       Impact factor: 4.272

Review 8.  The right team at the right time to go for a home run: tyrosine kinase activation by the TCR.

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9.  Mammalian T-lymphocyte antigen receptor genes: genetic and nongenetic potential to generate variability.

Authors:  J T Epplen; J Chluba; C Hardt; A Hinkkanen; V Steimle; H Stockinger
Journal:  Hum Genet       Date:  1987-04       Impact factor: 4.132

10.  Human CD3-epsilon gene contains three miniexons and is transcribed from a non-TATA promoter.

Authors:  H C Clevers; S Dunlap; T E Wileman; C Terhorst
Journal:  Proc Natl Acad Sci U S A       Date:  1988-11       Impact factor: 11.205
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