Literature DB >> 3863144

Cerebellin: a quantifiable marker for Purkinje cell maturation.

J R Slemmon, W Danho, J L Hempstead, J I Morgan.   

Abstract

The cerebellum-specific hexadecapeptide cerebellin has been localized by immunocytochemical means to the perikarya and dendrites of cerebellar Purkinje cells. Biochemical analysis using ion-pairing HPLC shows cerebellin to first appear 5 days after birth, whereafter levels rise to a maximum at 25 days postpartum, and then decline to stable adult values. This same pattern of development occurs with a lag of approximately 5 days for the major metabolite of cerebellin, des-Ser1-cerebellin. The immunocytochemical picture of cerebellin in developing Purkinje cells mirrors the biochemical data. These results show that cerebellins represent unique quantifiable markers for the investigation of Purkinje cell maturation and lend support to the feasibility of using unique endogenous peptides to chart neurodevelopment.

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Year:  1985        PMID： 3863144      PMCID： PMC391327          DOI： 10.1073/pnas.82.20.7145

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  12 in total

1.  The ontogenetic development of synaptic junctions, synaptic activation and responsiveness to neurotransmitter substances in rat cerebellar purkinje cells.

Authors:  D J Woodward; B J Hoffer; G R Siggins; F E Bloom
Journal:  Brain Res       Date:  1971-11       Impact factor: 3.252

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Authors:  J Altman
Journal:  J Comp Neurol       Date:  1972-07       Impact factor: 3.215

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Authors:  J Altman
Journal:  J Comp Neurol       Date:  1972-08       Impact factor: 3.215

4.  Maturation of climbing fiber responses in the rat.

Authors:  F Crepel
Journal:  Brain Res       Date:  1971-12-10       Impact factor: 3.252

5.  Autoradiographic and histological studies of postnatal neurogenesis. 3. Dating the time of production and onset of differentiation of cerebellar microneurons in rats.

Authors:  J Altman
Journal:  J Comp Neurol       Date:  1969-07       Impact factor: 3.215

6.  Histogenesis of the cerebellar climbing fiber in the rat.

Authors:  J L O'Leary; J Inukai; J M Smith
Journal:  J Comp Neurol       Date:  1971-07       Impact factor: 3.215

7.  Isolation and sequencing of two cerebellum-specific peptides.

Authors:  J R Slemmon; R Blacher; W Danho; J L Hempstead; J I Morgan
Journal:  Proc Natl Acad Sci U S A       Date:  1984-11       Impact factor: 11.205

8.  Remodelling during development of the Purkinje cell dendritic tree in the mouse.

Authors:  M Sadler; M Berry
Journal:  Proc R Soc Lond B Biol Sci       Date:  1984-05-22

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Authors:  T Shimono; S Nosaka; K Sasaki
Journal:  Brain Res       Date:  1976-05-28       Impact factor: 3.252

10.  Evidence for loss of Purkinje cell dendrites during late development: a morphometric Golgi analysis in the mouse.

Authors:  G M Weiss; J J Pysh
Journal:  Brain Res       Date:  1978-10-13       Impact factor: 3.252
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  12 in total

1.  Expression of the yes proto-oncogene in cerebellar Purkinje cells.

Authors:  M Sudol; C F Kuo; L Shigemitsu; A Alvarez-Buylla
Journal:  Mol Cell Biol       Date:  1989-10       Impact factor: 4.272

2.  Monoclonal antibodies to cerebellar pinceau terminals obtained after immunization with brain mRNA-injected Xenopus oocytes.

Authors:  G Tigyi; C Matute; R Miledi
Journal:  Proc Natl Acad Sci U S A       Date:  1990-01       Impact factor: 11.205

3.  The neuropeptide cerebellin is a marker for two similar neuronal circuits in rat brain.

Authors:  E Mugnaini; J I Morgan
Journal:  Proc Natl Acad Sci U S A       Date:  1987-12       Impact factor: 11.205

4.  Cbln1 is essential for interaction-dependent secretion of Cbln3.

Authors:  Dashi Bao; Zhen Pang; Marc A Morgan; Jennifer Parris; Yongqi Rong; Leyi Li; James I Morgan
Journal:  Mol Cell Biol       Date:  2006-10-09       Impact factor: 4.272

5.  Cbln3, a novel member of the precerebellin family that binds specifically to Cbln1.

Authors:  Z Pang; J Zuo; J I Morgan
Journal:  J Neurosci       Date:  2000-09-01       Impact factor: 6.167

6.  Precerebellin is a cerebellum-specific protein with similarity to the globular domain of complement C1q B chain.

Authors:  Y Urade; J Oberdick; R Molinar-Rode; J I Morgan
Journal:  Proc Natl Acad Sci U S A       Date:  1991-02-01       Impact factor: 11.205

7.  Monoclonal antibodies to a rat nestin fusion protein recognize a 220-kDa polypeptide in subsets of fetal and adult human central nervous system neurons and in primitive neuroectodermal tumor cells.

Authors:  T Tohyama; V M Lee; L B Rorke; M Marvin; R D McKay; J Q Trojanowski
Journal:  Am J Pathol       Date:  1993-07       Impact factor: 4.307

8.  Isolation, sequence, and developmental profile of a brain-specific polypeptide, PEP-19.

Authors:  R Ziai; Y C Pan; J D Hulmes; L Sangameswaran; J I Morgan
Journal:  Proc Natl Acad Sci U S A       Date:  1986-11       Impact factor: 11.205

9.  GNG13 Is a Potential Marker of the State of Health of Alzheimer's Disease Patients' Cerebellum.

Authors:  Cristina Sanfilippo; Giuseppe Musumeci; Maria Kazakova; Venera Mazzone; Paola Castrogiovanni; Rosa Imbesi; Michelino Di Rosa
Journal:  J Mol Neurosci       Date:  2020-10-15       Impact factor: 3.444

10.  Characterization of Meteorin--an evolutionary conserved neurotrophic factor.

Authors:  Jesper Roland Jørgensen; Lachlan Thompson; Lone Fjord-Larsen; Christina Krabbe; Malene Torp; Nisse Kalkkinen; Claus Hansen; Lars Wahlberg
Journal:  J Mol Neurosci       Date:  2009-03-04       Impact factor: 3.444
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