Literature DB >> 3863102

Activation of retinoic acid by coenzyme A for the formation of ethyl retinoate.

D A Miller, H F DeLuca.   

Abstract

All-trans-retinoic acid is metabolized to a less polar metabolite in rat liver microsomes. This metabolite was proven to be ethyl retinoate by cochromatography on high-performance liquid chromatography, base hydrolysis to all-trans-retinoic acid, and gas chromatography/mass spectral analysis. The formation of ethyl retinoate is a specific enzymatic process; the apparent Km for all-trans-retinoic acid is 9.8 microM. The production of ethyl retinoate is greatly stimulated by the addition of coenzyme A, suggesting the formation of a retinoic acid-coenzyme A intermediate (retinoyl-coenzyme A).

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Year:  1985        PMID： 3863102      PMCID： PMC390727          DOI： 10.1073/pnas.82.19.6419

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  7 in total

1.  A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

Authors:  M M Bradford
Journal:  Anal Biochem       Date:  1976-05-07       Impact factor: 3.365

2.  In vitro epoxidation of all-trans-retinoic acid in rat tissue homogenates.

Authors:  W K Sietsema; H F DeLuca
Journal:  Biochem Biophys Res Commun       Date:  1979-10-29       Impact factor: 3.575

3.  The biological activity of rat intestinal retinoic acid metabolites in the vaginal smear assay.

Authors:  A Stephens-Jarnagin; W K Sietsema; D A Miller; H F DeLuca
Journal:  Arch Biochem Biophys       Date:  1983-02-01       Impact factor: 4.013

4.  The biological activity of retinotaurine.

Authors:  K L Skare; W K Sietsema; H F DeLuca
Journal:  J Nutr       Date:  1982-08       Impact factor: 4.798

5.  Origin of some derivatives of retinoic acid found in rat bile.

Authors:  K Lippel; J A Olson
Journal:  J Lipid Res       Date:  1968-09       Impact factor: 5.922

6.  Metabolites of all-trans-retinoic acid in bile: identification of all-trans- and 13-cis-retinoyl glucuronides.

Authors:  M H Zile; R C Inhorn; H F DeLuca
Journal:  J Biol Chem       Date:  1982-04-10       Impact factor: 5.157

7.  Metabolism of retinoic acid in vivo in the vitamin A-deficient rat.

Authors:  D P Silva; H F DeLuca
Journal:  Biochem J       Date:  1982-07-15       Impact factor: 3.857
  7 in total
  4 in total

1.  Chemical synthesis of all-trans-[11-3H]retinoyl beta-glucuronide and its metabolism in rats in vivo.

Authors:  A B Barua; J A Olson
Journal:  Biochem J       Date:  1989-10-15       Impact factor: 3.857

Review 2.  Acitretin (Neotigason). A review of pharmacokinetics and teratogenicity and hypothesis on metabolic pathways.

Authors:  M L Bouvy; M C Sturkenboom; M C Cornel; L T De Jong-Van den Berg; B H Stricker; H Wesseling
Journal:  Pharm Weekbl Sci       Date:  1992-04-24

3.  Synthesis of coenzyme A ester of retinoic acid: intermediate in vitamin A metabolism.

Authors:  A Kutner; B Renstrom; H K Schnoes; H F DeLuca
Journal:  Proc Natl Acad Sci U S A       Date:  1986-09       Impact factor: 11.205

4.  Subcellular distribution and characteristics of trihydroxycoprostanoyl-CoA synthetase in rat liver.

Authors:  L Schepers; M Casteels; K Verheyden; G Parmentier; S Asselberghs; H J Eyssen; G P Mannaerts
Journal:  Biochem J       Date:  1989-01-01       Impact factor: 3.857
  4 in total

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