Literature DB >> 3858871

Type beta transforming growth factor/growth inhibitor stimulates entry of monolayer cultures of AKR-2B cells into S phase after a prolonged prereplicative interval.

G D Shipley, R F Tucker, H L Moses.   

Abstract

Type beta transforming growth factor/growth inhibitor (TGF-beta/GI) is demonstrated to be a potent stimulator of DNA synthesis in AKR-2B mouse embryo cells with a prolonged (greater than 24 hr) prereplicative phase when compared with other growth factors (epidermal growth factor, platelet-derived growth factor, or fibroblast growth factor) that induce DNA synthesis 12-14 hr after stimulation. In addition, TGF-beta/GI inhibits the early peak of DNA synthesis produced by EGF and insulin before the later stimulatory effects of TGF-beta/GI become manifest. TGF-beta/GI induces a marked morphologic transformation in these cells prior to their entry into S phase. Like the other growth factors, TGF-beta/GI stimulates an early increase in the rate of protein synthesis in AKR-2B cells and its stimulatory effect on DNA synthesis is enhanced by insulin. The data show that this molecule is a growth factor for certain mesenchymal cells in monolayer culture but only after a prereplicative phase that is significantly longer than that of other growth factors.

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Year:  1985        PMID： 3858871      PMCID： PMC397952          DOI： 10.1073/pnas.82.12.4147

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  22 in total

1.  Gene expression in chemically transformed mouse embryo cells: selective enhancement of the expression of C type RNA tumor virus genes.

Authors:  M J Getz; H M Reiman; G P Siegal; T J Quinlan; J Proper; P K Elder; H L Moses
Journal:  Cell       Date:  1977-08       Impact factor: 41.582

2.  Effect of cell proliferation on levels and diversity of poly(A)-containing mRNA.

Authors:  M J Getz; P K Elder; E W Benz; R E Stephens; H L Moses
Journal:  Cell       Date:  1976-02       Impact factor: 41.582

3.  Density-dependent regulation of growth of BSC-1 cells in cell culture: growth inhibitors formed by the cells.

Authors:  R W Holley; R Armour; J H Baldwin
Journal:  Proc Natl Acad Sci U S A       Date:  1978-04       Impact factor: 11.205

4.  Epidermal growth factor and a new derivative. Rapid isolation procedures and biological and chemical characterization.

Authors:  C R Savage; S Cohen
Journal:  J Biol Chem       Date:  1972-12-10       Impact factor: 5.157

5.  Growth inhibitor from BSC-1 cells closely related to platelet type beta transforming growth factor.

Authors:  R F Tucker; G D Shipley; H L Moses; R W Holley
Journal:  Science       Date:  1984-11-09       Impact factor: 47.728

6.  Specific binding to cultured cells of 125I-labeled type beta transforming growth factor from human platelets.

Authors:  R F Tucker; E L Branum; G D Shipley; R J Ryan; H L Moses
Journal:  Proc Natl Acad Sci U S A       Date:  1984-11       Impact factor: 11.205

7.  Differential effects of epidermal growth factor, transforming growth factor, and insulin on DNA and protein synthesis and morphology in serum-free cultures of AKR-2B cells.

Authors:  G D Shipley; C B Childs; M E Volkenant; H L Moses
Journal:  Cancer Res       Date:  1984-02       Impact factor: 12.701

8.  Purification of kidney epithelial cell growth inhibitors.

Authors:  R W Holley; P Böhlen; R Fava; J H Baldwin; G Kleeman; R Armour
Journal:  Proc Natl Acad Sci U S A       Date:  1980-10       Impact factor: 11.205

9.  Characterization of a membrane receptor for transforming growth factor-beta in normal rat kidney fibroblasts.

Authors:  C A Frolik; L M Wakefield; D M Smith; M B Sporn
Journal:  J Biol Chem       Date:  1984-09-10       Impact factor: 5.157

10.  Transforming growth factor-beta controls receptor levels for epidermal growth factor in NRK fibroblasts.

Authors:  R K Assoian; C A Frolik; A B Roberts; D M Miller; M B Sporn
Journal:  Cell       Date:  1984-01       Impact factor: 41.582
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  30 in total

1.  TGF-beta in mammary development and neoplasia.

Authors:  C L Arteaga; H L Moses
Journal:  J Mammary Gland Biol Neoplasia       Date:  1996-10       Impact factor: 2.673

2.  A phorbol ester-regulated ribonuclease system controlling transforming growth factor beta 1 gene expression in hematopoietic cells.

Authors:  R E Wager; R K Assoian
Journal:  Mol Cell Biol       Date:  1990-11       Impact factor: 4.272

3.  Transforming growth factor beta as a potential tumor progression factor among hyperdiploid glioblastoma cultures: evidence for the role of platelet-derived growth factor.

Authors:  M T Jennings; C E Hart; P A Commers; J A Whitlock; D Martincic; R J Maciunas; P L Moots; T M Shehab
Journal:  J Neurooncol       Date:  1997-02       Impact factor: 4.130

4.  Transforming growth factor beta induces myoblast differentiation in the presence of mitogens.

Authors:  A Zentella; J Massagué
Journal:  Proc Natl Acad Sci U S A       Date:  1992-06-01       Impact factor: 11.205

5.  Induction of c-sis mRNA and activity similar to platelet-derived growth factor by transforming growth factor beta: a proposed model for indirect mitogenesis involving autocrine activity.

Authors:  E B Leof; J A Proper; A S Goustin; G D Shipley; P E DiCorleto; H L Moses
Journal:  Proc Natl Acad Sci U S A       Date:  1986-04       Impact factor: 11.205

6.  Insulin-like synergistic stimulation of DNA synthesis in Swiss 3T3 cells by the BSC-1 cell-derived growth inhibitor related to transforming growth factor type beta.

Authors:  K D Brown; R W Holley
Journal:  Proc Natl Acad Sci U S A       Date:  1987-06       Impact factor: 11.205

7.  Modulation of type beta transforming growth factor activity in bone cultures by osteotropic hormones.

Authors:  J Pfeilschifter; G R Mundy
Journal:  Proc Natl Acad Sci U S A       Date:  1987-04       Impact factor: 11.205

8.  Induction of fibronectin gene transcription and mRNA is a primary response to growth-factor stimulation of AKR-2B cells.

Authors:  S P Blatti; D N Foster; G Ranganathan; H L Moses; M J Getz
Journal:  Proc Natl Acad Sci U S A       Date:  1988-02       Impact factor: 11.205

9.  Enhanced jun gene expression is an early genomic response to transforming growth factor beta stimulation.

Authors:  L Pertovaara; L Sistonen; T J Bos; P K Vogt; J Keski-Oja; K Alitalo
Journal:  Mol Cell Biol       Date:  1989-03       Impact factor: 4.272

10.  Opposite and independent actions of cyclic AMP and transforming growth factor beta in the regulation of type 1 plasminogen activator inhibitor expression.

Authors:  F W Thalacker; M Nilsen-Hamilton
Journal:  Biochem J       Date:  1992-11-01       Impact factor: 3.857
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