Literature DB >> 3858838

Glycolysis and methylaminoisobutyrate uptake in rat-1 cells transfected with ras or myc oncogenes.

E Racker, R J Resnick, R Feldman.   

Abstract

A high rate of aerobic glycolysis was catalyzed by rat-1 cells transfected with a ras oncogene (ras cells); rat-1 cells and rat-1 cells transfected with myc oncogene (myc cells) showed a low rate of glycolysis that was increased after exposure of the cells to type B transforming growth factor (TGF-beta). The uptake of radioactive methylaminoisobutyric acid or L-methionine via system A of amino acid transport also was accelerated after exposure of these cells to TGF-beta, with the myc cells being most sensitive and the ras cells least sensitive. Methionine was found to be a potent inhibitor of glycolysis in ras cells as well as in rat-1 or myc cells that were exposed to TGF-beta. We propose a relationship between the product of the ras oncogene (p21) and the protein(s) induced by exposure to TGF-beta.

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Year:  1985        PMID： 3858838      PMCID： PMC397819          DOI： 10.1073/pnas.82.11.3535

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  14 in total

1.  Repression, derepression, transinhibition, and trans-stimulation of amino acid transport in rat hepatocytes and four rat hepatoma cell lines in culture.

Authors:  D S Kelley; V R Potter
Journal:  J Biol Chem       Date:  1979-07-25       Impact factor: 5.157

2.  Regulatory mechanisms in carbohydrate metabolism. IX. Stimulation of aerobic glycolysis by energy-linked ion transport and inhibition by dextran sulfate.

Authors:  P Scholnick; D Lang; E Racker
Journal:  J Biol Chem       Date:  1973-07-25       Impact factor: 5.157

3.  Energy-linked ion translocation in submitochondrial particles. II. Properties of submitochondrial particles capable of Ca++ translocation.

Authors:  R O Christiansen; H Steensland; A Loyter; J Saltzgaber; E Racker
Journal:  J Biol Chem       Date:  1969-08-25       Impact factor: 5.157

4.  Stimulation of glycolysis and amino acid uptake in NRK-49F cells by transforming growth factor beta and epidermal growth factor.

Authors:  P Boerner; R J Resnick; E Racker
Journal:  Proc Natl Acad Sci U S A       Date:  1985-03       Impact factor: 11.205

5.  Post-translational control by carrier availability of amino acid transport in fetal human fibroblasts.

Authors:  G C Gazzola; V Dall'Asta; R Franchi-Gazzola; O Bussolati; N Longo; G G Guidotti
Journal:  Biochem Biophys Res Commun       Date:  1984-04-16       Impact factor: 3.575

6.  Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes.

Authors:  H Land; L F Parada; R A Weinberg
Journal:  Nature       Date:  1983 Aug 18-24       Impact factor: 49.962

7.  Growth regulation and amino acid transport in epithelial cells: influence of culture conditions and transformation on A, ASC, and L transport activities.

Authors:  P Boerner; M H Saier
Journal:  J Cell Physiol       Date:  1982-11       Impact factor: 6.384

8.  Regulation of amino acid transport systems by amino acid depletion and supplementation in monolayer cultures of rat hepatocytes.

Authors:  D S Kelley; V R Potter
Journal:  J Biol Chem       Date:  1978-12-25       Impact factor: 5.157

9.  Altered methionine metabolism occurs in all members of a set of diverse human tumor cell lines.

Authors:  P H Stern; C D Wallace; R M Hoffman
Journal:  J Cell Physiol       Date:  1984-04       Impact factor: 6.384

10.  Increased uptake of amino acids and 2-deoxy-D-glucose by virus-transformed cells in culture.

Authors:  K J Isselbacher
Journal:  Proc Natl Acad Sci U S A       Date:  1972-03       Impact factor: 11.205
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  40 in total

1.  Protein turnover in 3T3 cells transformed with the oncogene c-H-ras1.

Authors:  J M Gunn; G James
Journal:  Biochem J       Date:  1992-04-15       Impact factor: 3.857

2.  Human radiation dosimetry of [11C]MeAIB, a new tracer for imaging of system A amino acid transport.

Authors:  Tuula Tolvanen; Kjell Någren; Meixiang Yu; Eija Sutinen; Katja Havu-Aurén; Sirkku Jyrkkiö; Markku Asola; Eira Kotoneva; Pirjo Nuutila; Heikki Minn
Journal:  Eur J Nucl Med Mol Imaging       Date:  2006-05-24       Impact factor: 9.236

3.  Uncharged tRNA-phosphofructokinase interaction in amino acid deficiency.

Authors:  M Rabinovitz
Journal:  Amino Acids       Date:  1996-06       Impact factor: 3.520

4.  Long-term effects of carbon containing engineered nanomaterials and asbestos in the lung: one year postexposure comparisons.

Authors:  Anna A Shvedova; Naveena Yanamala; Elena R Kisin; Alexey V Tkach; Ashley R Murray; Ann Hubbs; Madalina M Chirila; Phouthone Keohavong; Lyudmila P Sycheva; Valerian E Kagan; Vincent Castranova
Journal:  Am J Physiol Lung Cell Mol Physiol       Date:  2013-11-08       Impact factor: 5.464

5.  A unifying model of the cell proliferation emphasizing plasma membrane fluxes.

Authors:  E Cervén
Journal:  Experientia       Date:  1990-10-15

Review 6.  Drugging the undruggable RAS: Mission possible?

Authors:  Adrienne D Cox; Stephen W Fesik; Alec C Kimmelman; Ji Luo; Channing J Der
Journal:  Nat Rev Drug Discov       Date:  2014-10-17       Impact factor: 84.694

7.  Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro.

Authors:  A B Roberts; M B Sporn; R K Assoian; J M Smith; N S Roche; L M Wakefield; U I Heine; L A Liotta; V Falanga; J H Kehrl
Journal:  Proc Natl Acad Sci U S A       Date:  1986-06       Impact factor: 11.205

8.  miR-146b antagomir-treated human Tregs acquire increased GVHD inhibitory potency.

Authors:  Yunjie Lu; Keli L Hippen; Amanda L Lemire; Jian Gu; Weizhi Wang; Xuhao Ni; Parvathi Ranganathan; Bruce L Levine; James L Riley; Carl H June; Laurence A Turka; David H Munn; Ramiro Garzon; Ling Lu; Bruce R Blazar
Journal:  Blood       Date:  2016-08-02       Impact factor: 22.113

9.  De novo lipogenesis represents a therapeutic target in mutant Kras non-small cell lung cancer.

Authors:  Anju Singh; Christian Ruiz; Kavita Bhalla; John A Haley; Qing Kay Li; George Acquaah-Mensah; Emily Montal; Kuladeep R Sudini; Ferdinandos Skoulidis; Ignacio I Wistuba; Vassiliki Papadimitrakopoulou; John V Heymach; Laszlo G Boros; Edward Gabrielson; Julian Carretero; Kwok-Kin Wong; John D Haley; Shyam Biswal; Geoffrey D Girnun
Journal:  FASEB J       Date:  2018-06-15       Impact factor: 5.191

10.  The role of glucose metabolism and glucose-associated signalling in cancer.

Authors:  Rainer Wittig; Johannes F Coy
Journal:  Perspect Medicin Chem       Date:  2008-01-18
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