Literature DB >> 3855548

Reovirus hemagglutinin mRNA codes for two polypeptides in overlapping reading frames.

H Ernst, A J Shatkin.   

Abstract

Human reovirus s1 mRNA, which codes for the viral hemagglutinin, also directs the synthesis of a previously unrecognized polypeptide of molecular mass 14 kDa in reticulocyte and wheat germ extracts. Hybrid-arrest of translation by selected restriction fragments of cloned S1 DNA indicated that synthesis of the 14-kDa polypeptide initiates at the second AUG. This was confirmed by NH2-terminal sequence analyses. The coding sequence for the 14-kDa polypeptide thus lies entirely within the hemagglutinin gene but in a different reading frame. Although not found in virions, the 14-kDa polypeptide apparently is formed in virus-infected mouse L cells, as demonstrated by comparison of [35S]methionine-labeled polypeptides in cell extracts with the corresponding in vitro products.

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Year:  1985        PMID： 3855548      PMCID： PMC396968          DOI： 10.1073/pnas.82.1.48

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  31 in total

1.  Overlapping genes in bacteriophage phiX174.

Authors:  B G Barrell; G M Air; C A Hutchison
Journal:  Nature       Date:  1976-11-04       Impact factor: 49.962

2.  Nucleotide sequences of 5'-terminal ribosome-protected initiation regions from two reovirus messages.

Authors:  M Kozak
Journal:  Nature       Date:  1977-09-29       Impact factor: 49.962

3.  Structural gene identification and mapping by DNA-mRNA hybrid-arrested cell-free translation.

Authors:  B M Paterson; B E Roberts; E L Kuff
Journal:  Proc Natl Acad Sci U S A       Date:  1977-10       Impact factor: 11.205

4.  Synthesis of polyoma proteins in vitro.

Authors:  L V Crawford; R F Gesteland
Journal:  J Mol Biol       Date:  1973-03-15       Impact factor: 5.469

5.  Polypeptide components of virions, top component and cores of reovirus type 3.

Authors:  R E Smith; H J Zweerink; W K Joklik
Journal:  Virology       Date:  1969-12       Impact factor: 3.616

6.  Migration of 40 S ribosomal subunits on messenger RNA in the presence of edeine.

Authors:  M Kozak; A J Shatkin
Journal:  J Biol Chem       Date:  1978-09-25       Impact factor: 5.157

7.  The nature of the polypeptide encoded by each of the 10 double-stranded RNA segments of reovirus type 3.

Authors:  M A McCrae; W K Joklik
Journal:  Virology       Date:  1978-09       Impact factor: 3.616

8.  Genetics of reovirus: identification of the ds RNA segments encoding the polypeptides of the mu and sigma size classes.

Authors:  T A Mustoe; R F Ramig; A H Sharpe; B N Fields
Journal:  Virology       Date:  1978-09       Impact factor: 3.616

9.  Identification of features in 5' terminal fragments from reovirus mRNA which are important for ribosome binding.

Authors:  M Kozak; A J Shatkin
Journal:  Cell       Date:  1978-01       Impact factor: 41.582

10.  Identification of two proteins encoded by the Saccharomyces cerevisiae GAL4 gene.

Authors:  A Laughon; R Driscoll; N Wills; R F Gesteland
Journal:  Mol Cell Biol       Date:  1984-02       Impact factor: 4.272
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  54 in total

1.  Binding of type 3 reovirus by a domain of the sigma 1 protein important for hemagglutination leads to infection of murine erythroleukemia cells.

Authors:  D H Rubin; J D Wetzel; W V Williams; J A Cohen; C Dworkin; T S Dermody
Journal:  J Clin Invest       Date:  1992-12       Impact factor: 14.808

2.  The nucleocapsid protein gene of bovine coronavirus is bicistronic.

Authors:  S D Senanayake; M A Hofmann; J L Maki; D A Brian
Journal:  J Virol       Date:  1992-09       Impact factor: 5.103

3.  Genetic characterization of a new mammalian reovirus, type 2 Winnipeg (T2W).

Authors:  Jieyuan Jiang; Laura Hermann; Kevin M Coombs
Journal:  Virus Genes       Date:  2006-10       Impact factor: 2.332

4.  Reovirus-induced apoptosis requires activation of transcription factor NF-kappaB.

Authors:  J L Connolly; S E Rodgers; P Clarke; D W Ballard; L D Kerr; K L Tyler; T S Dermody
Journal:  J Virol       Date:  2000-04       Impact factor: 5.103

5.  The second open reading frame of the avian reovirus S1 gene encodes a transcription-dependent and CRM1-independent nucleocytoplasmic shuttling protein.

Authors:  Celina Costas; José Martínez-Costas; Gustavo Bodelón; Javier Benavente
Journal:  J Virol       Date:  2005-02       Impact factor: 5.103

6.  Sequence diversity in S1 genes and S1 translation products of 11 serotype 3 reovirus strains.

Authors:  T S Dermody; M L Nibert; R Bassel-Duby; B N Fields
Journal:  J Virol       Date:  1990-10       Impact factor: 5.103

Review 7.  Mechanisms of reovirus bloodstream dissemination.

Authors:  Karl W Boehme; Caroline M Lai; Terence S Dermody
Journal:  Adv Virus Res       Date:  2013       Impact factor: 9.937

8.  Utilization of sialylated glycans as coreceptors enhances the neurovirulence of serotype 3 reovirus.

Authors:  Johnna M Frierson; Andrea J Pruijssers; Jennifer L Konopka; Dirk M Reiter; Ty W Abel; Thilo Stehle; Terence S Dermody
Journal:  J Virol       Date:  2012-10-03       Impact factor: 5.103

9.  Multiple viral core proteins are determinants of reovirus-induced acute myocarditis.

Authors:  B Sherry; M A Blum
Journal:  J Virol       Date:  1994-12       Impact factor: 5.103

10.  Overlapping genes in a yeast double-stranded RNA virus.

Authors:  M E Diamond; J J Dowhanick; M E Nemeroff; D F Pietras; C L Tu; J A Bruenn
Journal:  J Virol       Date:  1989-09       Impact factor: 5.103
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