Literature DB >> 3851741

The two intervening sequences of human beta- and gamma-globin pre-mRNAs are excised in a preferred temporal order in vitro.

K M Lang, V L van Santen, R A Spritz.   

Abstract

Splicing of complete synthetic human beta- and gamma-globin mRNA precursors (pre-mRNAs) follows a preferred pathway in vitro. In almost all molecules, excision of the first intervening sequence (IVS) is completed before excision of the second IVS initiates. However, in a very small fraction of molecules the order of IVS excision is reversed.

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Year:  1985        PMID： 3851741      PMCID： PMC554452          DOI： 10.1002/j.1460-2075.1985.tb03882.x

Source DB:  PubMed          Journal:  EMBO J        ISSN： 0261-4189            Impact factor:   11.598


  29 in total

1.  Specific transcription and RNA splicing defects in five cloned beta-thalassaemia genes.

Authors:  R Treisman; S H Orkin; T Maniatis
Journal:  Nature       Date:  1983-04-14       Impact factor: 49.962

2.  Abnormal splice in a mutant human beta-globin gene not at the site of a mutation.

Authors:  C Dobkin; R G Pergolizzi; P Bahre; A Bank
Journal:  Proc Natl Acad Sci U S A       Date:  1983-03       Impact factor: 11.205

3.  A single-base change at a splice site in a beta 0-thalassemic gene causes abnormal RNA splicing.

Authors:  R Treisman; N J Proudfoot; M Shander; T Maniatis
Journal:  Cell       Date:  1982-07       Impact factor: 41.582

4.  Abnormal RNA processing due to the exon mutation of beta E-globin gene.

Authors:  S H Orkin; H H Kazazian; S E Antonarakis; H Ostrer; S C Goff; J P Sexton
Journal:  Nature       Date:  1982-12-23       Impact factor: 49.962

5.  Splicing of adenovirus RNA in a cell-free transcription system.

Authors:  R A Padgett; S F Hardy; P A Sharp
Journal:  Proc Natl Acad Sci U S A       Date:  1983-09       Impact factor: 11.205

6.  "Silent" nucleotide substitution in a beta+-thalassemia globin gene activates splice site in coding sequence RNA.

Authors:  M E Goldsmith; R K Humphries; T Ley; A Cline; J A Kantor; A W Nienhuis
Journal:  Proc Natl Acad Sci U S A       Date:  1983-04       Impact factor: 11.205

7.  Normal and mutant human beta-globin pre-mRNAs are faithfully and efficiently spliced in vitro.

Authors:  A R Krainer; T Maniatis; B Ruskin; M R Green
Journal:  Cell       Date:  1984-04       Impact factor: 41.582

8.  Human beta-globin pre-mRNA synthesized in vitro is accurately spliced in Xenopus oocyte nuclei.

Authors:  M R Green; T Maniatis; D A Melton
Journal:  Cell       Date:  1983-03       Impact factor: 41.582

9.  beta-Thalassemia in American Blacks: novel mutations in the "TATA" box and an acceptor splice site.

Authors:  S E Antonarakis; S H Irkin; T C Cheng; A F Scott; J P Sexton; S P Trusko; S Charache; H H Kazazian
Journal:  Proc Natl Acad Sci U S A       Date:  1984-02       Impact factor: 11.205

10.  RNA splice site selection: evidence for a 5' leads to 3' scanning model.

Authors:  K M Lang; R A Spritz
Journal:  Science       Date:  1983-06-24       Impact factor: 47.728
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  12 in total

1.  Redefinition of exon 7 in the COL1A1 gene of type I collagen by an intron 8 splice-donor-site mutation in a form of osteogenesis imperfecta: influence of intron splice order on outcome of splice-site mutation.

Authors:  U Schwarze; B J Starman; P H Byers
Journal:  Am J Hum Genet       Date:  1999-08       Impact factor: 11.025

2.  The late spliced 19S and 16S RNAs of simian virus 40 can be synthesized from a common pool of transcripts.

Authors:  P J Good; R C Welch; W S Ryu; J E Mertz
Journal:  J Virol       Date:  1988-02       Impact factor: 5.103

3.  Sequence of the polypyrimidine tract of the 3'-terminal 3' splicing signal can affect intron-dependent pre-mRNA processing in vivo.

Authors:  X Liu; J E Mertz
Journal:  Nucleic Acids Res       Date:  1996-05-01       Impact factor: 16.971

4.  Direct, sequence-specific binding of the human U1-70K ribonucleoprotein antigen protein to loop I of U1 small nuclear RNA.

Authors:  C S Surowy; V L van Santen; S M Scheib-Wixted; R A Spritz
Journal:  Mol Cell Biol       Date:  1989-10       Impact factor: 4.272

5.  In vitro splicing pathways of pre-mRNAs containing multiple intervening sequences?

Authors:  K M Lang; R A Spritz
Journal:  Mol Cell Biol       Date:  1987-10       Impact factor: 4.272

6.  Presence of a polyadenylated RNA fragment encoding the membrane domain for immunoglobulin alpha chain indicates that mRNAs for both secreted and membrane-bound alpha chains can be produced from the same RNA transcript.

Authors:  J Stavnezer
Journal:  Nucleic Acids Res       Date:  1986-08-11       Impact factor: 16.971

7.  Polyadenylation site selection cannot occur in vivo after excision of the 3'-terminal intron.

Authors:  X Liu; J E Mertz
Journal:  Nucleic Acids Res       Date:  1993-11-11       Impact factor: 16.971

8.  Model for alternative RNA processing in human calcitonin gene expression.

Authors:  R A Bovenberg; W P van de Meerendonk; P D Baas; P H Steenbergh; C J Lips; H S Jansz
Journal:  Nucleic Acids Res       Date:  1986-11-25       Impact factor: 16.971

9.  Alternative splicing of SV40 early pre-mRNA in vitro.

Authors:  V L van Santen; R A Spritz
Journal:  Nucleic Acids Res       Date:  1986-12-22       Impact factor: 16.971

10.  Rare autosomal recessive cardiac valvular form of Ehlers-Danlos syndrome results from mutations in the COL1A2 gene that activate the nonsense-mediated RNA decay pathway.

Authors:  Ulrike Schwarze; Ryu-Ichiro Hata; Victor A McKusick; Hiroshi Shinkai; H Eugene Hoyme; Reed E Pyeritz; Peter H Byers
Journal:  Am J Hum Genet       Date:  2004-04-09       Impact factor: 11.025
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