Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 RNA splice site selection: evidence for a 5' leads to 3' scanning model.

Literature DB >> 6304877

RNA splice site selection: evidence for a 5' leads to 3' scanning model.

Abstract

Human G gamma-globin genes containing tandem duplications of the donor (5') or acceptor (3') RNA splice sites of the second intervening sequence were constructed in order to ascertain the directionality of RNA splice site selection. These genes were introduced into cultured monkey cells, and their transcripts were analyzed. Transcripts of these duplication variants were spliced only at the proximal copy of the duplicated splice sites. These data are consistent with a 5' leads to 3' model of splice site selection.

Entities: Species

Mesh：

Substances：
RNA, Messenger
Globins

Year: 1983 PMID： 6304877 DOI： 10.1126/science.6304877

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

Keyword Cloud
Cited

34 in total

1. Redefinition of exon 7 in the COL1A1 gene of type I collagen by an intron 8 splice-donor-site mutation in a form of osteogenesis imperfecta: influence of intron splice order on outcome of splice-site mutation.

Authors: U Schwarze; B J Starman; P H Byers
Journal: Am J Hum Genet Date: 1999-08 Impact factor: 11.025

2. RNA molecules containing exons originating from different members of the cytochrome P450 2C gene subfamily (CYP2C) in human epidermis and liver.

Authors: P G Zaphiropoulos
Journal: Nucleic Acids Res Date: 1999-07-01 Impact factor: 16.971

3. Sequences involved in the control of adenovirus L1 alternative RNA splicing.

Authors: J P Kreivi; K Zerivitz; G Akusjärvi
Journal: Nucleic Acids Res Date: 1991-05-11 Impact factor: 16.971

4. Analysis of the RPGR gene in 11 pedigrees with the retinitis pigmentosa type 3 genotype: paucity of mutations in the coding region but splice defects in two families.

Authors: R Fujita; M Buraczynska; L Gieser; W Wu; P Forsythe; M Abrahamson; S G Jacobson; P A Sieving; S Andréasson; A Swaroop
Journal: Am J Hum Genet Date: 1997-09 Impact factor: 11.025

RNA splice site selection: evidence for a 5' leads to 3' scanning model.

1. Redefinition of exon 7 in the COL1A1 gene of type I collagen by an intron 8 splice-donor-site mutation in a form of osteogenesis imperfecta: influence of intron splice order on outcome of splice-site mutation.

2. RNA molecules containing exons originating from different members of the cytochrome P450 2C gene subfamily (CYP2C) in human epidermis and liver.

3. Sequences involved in the control of adenovirus L1 alternative RNA splicing.

4. Analysis of the RPGR gene in 11 pedigrees with the retinitis pigmentosa type 3 genotype: paucity of mutations in the coding region but splice defects in two families.

5. Identification of RNA splicing errors resulting in human ornithine transcarbamylase deficiency.

6. Ordered splicing of thymidine kinase pre-mRNA during the S phase of the cell cycle.

7. Imprecise excision of the Caenorhabditis elegans transposon Tc1 creates functional 5' splice sites.

8. The 5' and 3' splice sites come together via a three dimensional diffusion mechanism.

9. Exon definition may facilitate splice site selection in RNAs with multiple exons.

10. Splice site selection in polyomavirus late pre-mRNA processing.