Literature DB >> 3851

Sperm diaphorase: genetic polymorphism of a sperm-specific enzyme in man.

K Caldwell, E T Blake, G F Sensabaugh.   

Abstract

Human sperm contains en enzyme with diaphorase activity that appears to be unique to sperm. Electrophoretic analysis of the diaphorase activity in sperm of different individuals reveals three phenotypic patterns. This polymorphism can be explained in terms of two alleles segregating at an autosomal locus; the allele frequencies have been determined to be 0.71 and 0.29. This appears to be the first reported example of a sperm-specific genetic polymorphism in man; its existence raises a number of genetic and biochemical questions.

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Year:  1976        PMID： 3851     DOI： 10.1126/science.3851

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  9 in total

1.  Leukocytes and oxidative stress: dilemma for sperm function and male fertility.

Authors:  Ralf R Henkel
Journal:  Asian J Androl       Date:  2010-11-15       Impact factor: 3.285

Review 2.  Free radical and superoxide reactivity detection in semen quality assessment: past, present, and future.

Authors:  Jaime Gosalvez; Eva Tvrda; Ashok Agarwal
Journal:  J Assist Reprod Genet       Date:  2017-03-25       Impact factor: 3.412

3.  DIA3 phenotyping in human tissues, dental pulps, and hair roots by isoelectric focusing.

Authors:  A Kido; N Komatsu; M Oya; S Seikyama
Journal:  Z Rechtsmed       Date:  1988

4.  [Typing of gonadospecific diaphorase (DIA3) in seminal stains and esterase D typing in seminal and saliva stains (author's transl)].

Authors:  I Oepen; B Peters; N Salzmann; G Wehr
Journal:  Z Rechtsmed       Date:  1980

5.  A new electrophoretically distinguishable variant of human diaphorase locus 3(DIA3):DIA3 6-1.

Authors:  R Pawłowski
Journal:  Hum Genet       Date:  1990-01       Impact factor: 4.132

6.  DIA3 phenotyping in human semen and seminal stains by isoelectric focusing.

Authors:  A Kido; N Komatsu; M Oya
Journal:  Z Rechtsmed       Date:  1987

7.  Assignment of a structural gene for a fourth human diaphorase (DIA4) to chromosome 16 in man-mouse somatic cell hybrids.

Authors:  K H Grzeschik
Journal:  Hum Genet       Date:  1980-02       Impact factor: 4.132

8.  Investigations on the polymorphism of sperm diaphorase in man. Evidence for a third common allele, SD.

Authors:  P Kühnl; U Langanke; W Spielmann; M Neubauer
Journal:  Hum Genet       Date:  1977-12-29       Impact factor: 4.132

9.  Human FAD-dependent NAD(P)H diaphorase.

Authors:  Y H Edwards; J Potter; D A Hopkinson
Journal:  Biochem J       Date:  1980-05-01       Impact factor: 3.857
  9 in total

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