Estimation of myriad haplotype frequencies.

The present paper demonstrates algorithms for applying gene counting estimation of haplotype frequencies in very large genetic systems. A factor union representation of phenotypes is used which conveniently yields the sets of potential haplotypes and diplotypes for each phenotype. Methods for storing and rapidly retrieving the relevant haplotypes are given. An example with several hundred frequencies is given which required a few seconds computing time for each estimation iteration on a small computer. A computer program employing the methods described has been written in Fortran-77 and is available to any investigator on request.