Literature DB >> 3840154

Diazaquinomycin A, a new antifolate antibiotic, inhibits thymidylate synthase.

M Murata, T Miyasaka, H Tanaka, S Omura.   

Abstract

The inhibitory effect of diazaquinomycin A (DQM) on the growth of Enterococcus faecium was completely reversed by thymidine. Relatively large amounts of folate, dihydrofolate or leucovorin also reversed the activity of DQM. DQM showed cytotoxicity against Vero and Raji cells and the cytotoxicity was partially reversed by leucovorin or thymidine. With enzyme experiments, it was found that DQM inhibits TMP synthases from E. faecium and Ehrlich ascites carcinoma competitively with 5,10-methylenetetrahydrofolate, one of the substrates for the enzyme reaction.

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Year:  1985        PMID： 3840154     DOI： 10.7164/antibiotics.38.1025

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  7 in total

1.  Diazaquinomycin Biosynthetic Gene Clusters from Marine and Freshwater Actinomycetes.

Authors:  Jana Braesel; Jung-Ho Lee; Benoit Arnould; Brian T Murphy; Alessandra S Eustáquio
Journal:  J Nat Prod       Date:  2019-03-21       Impact factor: 4.050

Review 2.  Philosophy of new drug discovery.

Authors:  S Omura
Journal:  Microbiol Rev       Date:  1986-09

3.  Structure Determination, Functional Characterization, and Biosynthetic Implications of Nybomycin Metabolites from a Mining Reclamation Site-Associated Streptomyces.

Authors:  Xiachang Wang; Sherif I Elshahawi; Larissa V Ponomareva; Qing Ye; Yang Liu; Gregory C Copley; James C Hower; Bruce E Hatcher; Madan K Kharel; Steven G Van Lanen; Qing-Bai She; S Randal Voss; Jon S Thorson; Khaled A Shaaban
Journal:  J Nat Prod       Date:  2019-12-13       Impact factor: 4.050

4.  Pseudonocardians A-C, new diazaanthraquinone derivatives from a deap-sea actinomycete Pseudonocardia sp. SCSIO 01299.

Authors:  Sumei Li; Xinpeng Tian; Siwen Niu; Wenjun Zhang; Yuchan Chen; Haibo Zhang; Xianwen Yang; Weimin Zhang; Wenjun Li; Si Zhang; Jianhua Ju; Changsheng Zhang
Journal:  Mar Drugs       Date:  2011-08-23       Impact factor: 6.085

5.  Diazaquinomycins E-G, novel diaza-anthracene analogs from a marine-derived Streptomyces sp.

Authors:  Michael W Mullowney; Eoghainín Ó hAinmhire; Anam Shaikh; Xiaomei Wei; Urszula Tanouye; Bernard D Santarsiero; Joanna E Burdette; Brian T Murphy
Journal:  Mar Drugs       Date:  2014-06-11       Impact factor: 5.118

6.  Total synthesis of diazaquinomycins H and J using double Knorr cyclization in the presence of triisopropylsilane.

Authors:  Allan M Prior; Dianqing Sun
Journal:  RSC Adv       Date:  2019-01-14       Impact factor: 4.036

7.  Diaza-anthracene Antibiotics from a Freshwater-Derived Actinomycete with Selective Antibacterial Activity toward Mycobacterium tuberculosis.

Authors:  Michael W Mullowney; Chang Hwa Hwang; Andrew G Newsome; Xiaomei Wei; Urszula Tanouye; Baojie Wan; Skylar Carlson; Nanthida Joy Barranis; EoghainínÓ hAinmhire; Wei-Lun Chen; Kalyanaraman Krishnamoorthy; John White; Rachel Blair; Hyunwoo Lee; Joanna E Burdette; Pradipsinh K Rathod; Tanya Parish; Sanghyun Cho; Scott G Franzblau; Brian T Murphy
Journal:  ACS Infect Dis       Date:  2015-03-11       Impact factor: 5.084
  7 in total

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